Sebastien: All methods in NONMEM are -2LL based. Robert J. Bauer, Ph.D. Pharmacometrics R&D ICON Early Phase 820 W. Diamond Avenue Suite 100 Gaithersburg, MD 20878 Office: (215) 616-6428 Mobile: (925) 286-0769 [email protected] www.iconplc.com
-----Original Message----- From: [email protected] [mailto:[email protected]] On Behalf Of sbihorel Sent: Monday, January 16, 2017 3:13 AM To: [email protected] Subject: [NMusers] Objective function Hi, This might appear like a very naive question but I could not find the information in the NONMEM use guide: what is the value of the objective function for ITS, IMP, SAEM, and BAYES estimation methods in relation to the log likelihood? Is it the standard minus 2 times the log likelihood like for FO, FOCE, FOCEI, or LAPLACE methods? Thank you Sebastien <br /><br /> ICON plc made the following annotations. ------------------------------------------------------------------------------ This e-mail transmission may contain confidential or legally privileged information that is intended only for the individual or entity named in the e-mail address. If you are not the intended recipient, you are hereby notified that any disclosure, copying, distribution, or reliance upon the contents of this e-mail is strictly prohibited. If you have received this e-mail transmission in error, please reply to the sender, so that ICON plc can arrange for proper delivery, and then please delete the message. Thank You, ICON plc South County Business Park Leopardstown Dublin 18 Ireland Registered number: 145835
