One simple option is to stack simulation data files together, with
EVID=4 for the first (or the only) dose of the second file.
Leonid
On 3/9/2017 6:11 PM, Faelens, Ruben (Belgium) wrote:
Hi Penny,
Nonmem indeed calculates each subject one after the other. The random
values will therefore change. Maybe you can set the random seed every
time you simulate t=0, based on the subject ID?
This may also depend on your data file; have you tried ordering on time
(so the first 50 rows are all t=0 for subject 1 to 50) ?
This largely depends on the simulation software and its design:
As an example: Simulo samples all subjects together at simulation start,
after which it runs the trial design; so the same subjects are sampled
independent of subsequent trial design.
I do not know about other tools (TS.2, simulx, mrgsolve), maybe the
authors of these tools can specify?
Kind regards,
Ruben Faelens
*From:*[email protected]
[mailto:[email protected]] *On Behalf Of *Zhu, Penny
*Sent:* donderdag 9 maart 2017 19:19
*To:* [email protected]
*Subject:* [NMusers] question about random seed for simulation
Dear All
I have finished a multiple dose simulation for 600 subjects and want to
perform a single dose simulation (different sampling time) on the same
subjects (same ETA as the first simulation). I used the same seed for
the simulation step, it turned out the first subject was the same and
the rest of the subjects are not and I am not sure whether this was due
to the fact that the two simulation has different number TIME records.
If so, I wonder what is the proper way to set the simulation seed so
that the ETAs for the second simulation will be identical to the first
one.
I know that I could output the individual parameter estimate from the
first simulation and import them into the second one. But I was
thinking if the random seed can be synchronized between the two
simulation, it could be an easier solution.
Your help is very much appreciated!
Thank you very much and best regards!
* *
*Penny (Peijuan) Zhu, Ph.D.*
Associate Director Clinical Pharmacology
Cell: 862-926-9079
PD Bio-Pharma CDMA
Sandoz
1N025, 100 College Road West
Princeton, NJ 08540
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