Job Description: The Computational Modeling and Sciences (CMS) group in GSK R&D China is seeking a Mechanistic PBPK/PD Modeler to integrate ADME data into PBPK models that can be linked with systems pharmacology to understand drug safety and efficacy. Applicants should have a desire to drive model based drug design and development in support of projects. This role involves developing PBPK/QSP/QST models to influence critical decisions in drug discovery and development, from target selection to the identification of the best modality and delivery route to engage the target to the optimal dose selection including inputs into clinical trial design. Working in a dynamic and multidisciplinary environment the successful candidate will develop, calibrate and use complex QSP/QST models connected with PBPK models linking drug disposition and target biology with clinical outcomes for various diseases. This role will address the relationships between drug properties, its disposition and the pharmacological and toxicological response translating between in-vitro, in-vivo preclinical species and human. This involves the integration and interpretation of data from many sources to help drive project decisions. Responsibilities:
* Responsible for providing appropriate modeling support to Discovery Performance Units (DPU)/Therapeutic Areas (TA)/Platform Technology and Science (PTS) line and peer review modeling work from colleagues as appropriate, insuring high quality standards for the modeling work * Further develop unique expert modeling skills. Provide expert modeling consultancy, training and support to others in your unique areas of expertise * Develop and execute a modeling strategy for each DPU/TA/PTS line assigned insuring availability of appropriate modeling capability * Build, expand and refine the modeling capabilities and platforms * Promote and increase the reputation of the modeling both internally within R&D and externally including regulatory agencies * Aid the interpretation of the data we generate and integrate it with that of clinical and pre-clinical partners to help project decisions * Use modeling as a thinking tool to help generate better hypothesis and design better, model informed experiments * Provide consultancy and training resource to increase the overall kinetic thinking and modeling capability of staff both within the department and outside in PTS and R&D * Exceptional collaborative behaviours to build and maintain relationships with both R&D customers as well as the wider modeling community in GSK Basic Qualifications: * Advanced degree in chemical, mechanical or biomedical engineering, biochemistry, physics, applied mathematics, bioinformatics, scientific computing or related field * A minimum of 5 years experience of applying mechanism based mathematical modeling techniques in the pharmaceutical industry (e.g. PBPK or QSP or QST modeling) * Core competency in numerical analysis focusing on differential equations * Knowledge and understanding of drug delivery, absorption, distribution and metabolism, pharmacology and toxicology, PK/PD modeling, physiological based modeling and translational sciences * Experience of building, solving and using mathematical models to integrate available data and applying these to answer practical questions that have a positive impact on projects * Scientific computing and programming particularly Matlab and SimBiology * Experience of using at least one physiological based modeling software package e.g. GastroPlus or Simcyp * Evidence of identifying, developing, and applying innovative solutions to scientific and technological problems faced in systems modeling * Evidence of strong critical thinking skills, troubleshooting and problem solving skills * Demonstrated collaborative behaviors both within the computational community and with the modeling customers in pharma * Excellent written and oral communication skills and the ability to interact effectively with scientists in other disciplines with a positive, collegial, collaborative attitude * Successfully leading in a matrix environment, working across functions/disciplines * Evidence of developing self and others Preferred Qualifications: * PhD degree strongly preferred * Experience in one of: finite element, computational fluid dynamics, numerical optimization, agent based modeling, stochastic differential equations, advanced image analysis * Knowledge and understanding of systems biology, data analysis, image analysis and computational sciences Hiring Manager: [email protected] 15821883201 Hongkang Mei GSK monitors email communications sent to and from GSK in order to protect GSK, our employees, customers, suppliers and business partners, from cyber threats and loss of GSK Information. GSK monitoring is conducted with appropriate confidentiality controls and in accordance with local laws and after appropriate consultation.
