Dear All, We have an open vacancy for a PhD candidate:
As PhD student in the Department of Clinical Pharmacy and Toxicology, you will be involved in the innovative research line 'Targeted therapy and clonal evolution of heterogeneous tumors.' Specific treatment of cancer is increasingly chosen on the basis of the presence of specific somatic mutations or protein expression in the tumor. Due to tumor heterogeneity and clonal evolution this is a very dynamic process. For this reason, the most optimal targeted drug may change over time. The goal of this new research line is to develop and apply systems pharmacology models to predict the most optimal therapy for individual patients. The project focuses on the mathematical description of and ultimately prediction of tumor growth and tumor clone development during treatment of oncological and hematological diseases using targeted therapies such as tyrosine kinase inhibitors. Data concerning pharmacokinetics, pharmacodynamics (tumor growth and heterogeneity) and drug sensitivity will be combined to develop models for predicting the most optimal therapy for the individual patient in the future. The research will involve several pharmacometric software systems for PK/PD and systems pharmacology modelling such as NONMEM, PKSim and Mobi. This research will be performed in close collaboration with different departments that participate in the Leiden Network for Personalised Therapeutics (www.lnpt.nl<https://www.lumc.nl/org/lnpt/>). For more info about the vacancy see the link below: https://www.lumc.nl/over-het-lumc/werken-bij/vacatures-solliciteren/research-onderwijs/Onderzoeker-in-Opleiding-(OIO)-KFT?setlanguage=English&setcountry=en Best Regards, Dirk Jan Moes Dr. D.J.A.R. Moes, PharmD, PhD | Hospital Pharmacist Laboratory (TDM/Toxicology) / Pharmacometrician Leiden University Medical Center | Department of Clinical Pharmacy and Toxicology Contact: pGSM: +31715297960 | Mobile: +31643052862 | Email: [email protected]<mailto:[email protected]> Fax: +31715266106 | Visitors: Albinusdreef 2, Room: L1-13, 2333 ZA, Leiden, The Netherlands Regular mail: PO box: 9600, 2300 RC, Leiden, The Netherlands
