[NMusers] Numerical integreaion and change in clearance over time

[Pavel Belo]

Hello NONMEM Users,
 
When clearance changes over time, the classic analytical solution for 
the 2-compartment linear model is not correct.  Nevertheless, if the 
change is only ~30%, one can say it is still acceptable.  Time required 
to run an analytical and numerical models is drastically different, 
which can be important for decision making.  Did someone  had an 
experience submitting using analytical solution when clearance changes 
over time to an agency or a journal?  Can it be acceptable? 
 
Thanks,
Paul