Dear nmusers, I have trouble figuring out the cause of the error I am encountering:
0INDIVIDUAL NO. 1 ID= 2.00000000000000E+00 (WITHIN-INDIVIDUAL) DATA REC NO. 2 ... OCCURS DURING SEARCH FOR ETA AT INITIAL VALUE, ETA=0 F OR DERIVATIVE RETURNED BY PRED IS INFINITE (INF) OR NOT A NUMBER (NAN). To my own experience, this error is usually due to some mistakes in the coding, such as the div/0 error occurring at the dosing record. However, for this time, after I eliminated a few other possible causes, it appears that the error will occur whenever I remove the occasional variability from the model (by fixing variability to ZERO), and this makes no sense to me. I have attached a minimal reproducible example at the bottom. Any help is appreciated and thank you for your attention. Best Regards, Matthew $SIZES DIMTMP=1000 $PROBLEM MODEL $INPUT C ID DOSE_N AMT=DOSE_UM RATE=RATE_UM TIME CP_UM DV=CP_LN_UM MDV EVID $DATA DATAFILE_TEST.csv IGNORE=@ $SUBROUTINE ADVAN3 TRANS4 $PK ;SETTING LLOQ IF (NEWIND.EQ.0) THEN LN_LLOQ=-2.9999 ENDIF ;INTEROCCASION VARIABILITY OCC1=0 IF (DOSE_N.EQ.1) OCC1=1 OCC2=0 IF (DOSE_N.EQ.2) OCC2=1 OCC3=0 IF (DOSE_N.EQ.3) OCC3=1 OCC4=0 IF (DOSE_N.EQ.4) OCC4=1 OCC5=0 IF (DOSE_N.EQ.5) OCC5=1 OCC6=0 IF (DOSE_N.EQ.6) OCC6=1 OCC7=0 IF (DOSE_N.EQ.7) OCC7=1 OCC8=0 IF (DOSE_N.EQ.8) OCC8=1 OCC9=0 IF (DOSE_N.EQ.9) OCC9=1 OCC10=0 IF (DOSE_N.EQ.10) OCC10=1 OCC11=0 IF (DOSE_N.EQ.11) OCC11=1 OCC12=0 IF (DOSE_N.EQ.12) OCC12=1 ;THETA DEFINITION TVCL=THETA(1) TVV1=THETA(2) TVQ=THETA(3) TVV2=THETA(4) OMG_CL=THETA(5) OMG_V1=THETA(6) OMG_Q=THETA(7) OMG_V2=THETA(8) SGM_EXP=THETA(9) OMG_CL_OCC=THETA(10) ;ETA DEFINITION ETA_CL=OMG_CL*ETA(1) ETA_V1=OMG_V1*ETA(2) ETA_Q=OMG_Q*ETA(3) ETA_V2=OMG_V2*ETA(4) ETA_CL_OCC=OMG_CL_OCC*(OCC1*ETA(5)+OCC2*ETA(6)+OCC3*ETA(7)+OCC4*ETA(8)+OCC5*ETA(9)+OCC6*ETA(10)+OCC7*ETA(11)+OCC8*ETA(12)+OCC9*ETA(13)+OCC10*ETA(14)+OCC11*ETA(15)+OCC12*ETA(16)) ;EFFECT DEFINITION ;CLEARANCE POP_CL=TVCL CL=POP_CL*EXP(ETA_CL+ETA_CL_OCC) ;CENTRAL VOLUME POP_V1=TVV1 V1=POP_V1*EXP(ETA_V1) ;INTERCOMPARTMENTAL CLEARANCE POP_Q=TVQ Q=POP_Q*EXP(ETA_Q) ;PERIPHERAL VOLUME POP_V2=TVV2 V2=POP_V2*EXP(ETA_V2) ;REQUIRED CONSTANT S1=V1 $THETA (0,9,1000000) ;TVCL (0,18,1000000) ;TVV1 (0,0.75,1000000) ;TVQ (0,7,1000000) ;TVV2 (0,0.3,1000000) ;OMG_CL (0,0.3,1000000) ;OMG_V1 (0,0.3,1000000) ;OMG_Q (0,0.3,1000000) ;OMG_V2 (0,0.3,1000000) ;SGM_EXP (0,0.3,1000000) ;OMG_CL_OCC ;Change to 0 FIX to remove occasional variability $ERROR EPS_EXP=SGM_EXP*EPS(1) Y=LOG(F)+EPS_EXP $OMEGA BLOCK(1) 1 FIX ;ETA_CL $OMEGA BLOCK(1) 1 FIX ;ETA_V1 $OMEGA BLOCK(1) 1 FIX ;ETA_Q $OMEGA BLOCK(1) 1 FIX ;ETA_V2 $OMEGA BLOCK(1) 1 FIX ;ETA_CL_OCC1 ;Change to 0 FIX to remove occasional variability $OMEGA BLOCK(1) SAME ;ETA_CL_OCC2 $OMEGA BLOCK(1) SAME ;ETA_CL_OCC3 $OMEGA BLOCK(1) SAME ;ETA_CL_OCC4 $OMEGA BLOCK(1) SAME ;ETA_CL_OCC5 $OMEGA BLOCK(1) SAME ;ETA_CL_OCC6 $OMEGA BLOCK(1) SAME ;ETA_CL_OCC7 $OMEGA BLOCK(1) SAME ;ETA_CL_OCC8 $OMEGA BLOCK(1) SAME ;ETA_CL_OCC9 $OMEGA BLOCK(1) SAME ;ETA_CL_OCC10 $OMEGA BLOCK(1) SAME ;ETA_CL_OCC11 $OMEGA BLOCK(1) SAME ;ETA_CL_OCC12 $SIGMA 1 FIX ;EPS_EXP $ESTIMATION MAXEVAL=9999 PRINT=1 METHOD=1 INTERACTION NUMERICAL SLOW LAPLACIAN NOABORT $COVARIANCE PRINT=E C,ID,DOSE_N,AMT=DOSE_UM,RATE=RATE_UM,TIME,CP_UM,DV=CP_LN_UM,MDV,EVID .,2,1,32743.59651,5457.27,0,0,0,1,1 .,2,1,0,0,6,730,6.593044534,0,0 .,2,1,0,0,24,140,4.941642423,0,0 .,2,1,0,0,48,20,2.995732274,0,0 .,2,1,0,0,72,5.1,1.62924054,0,0 .,2,1,0,0,96,1.7,0.530628251,0,0 .,2,1,0,0,120,0.97,-0.030459207,0,0 .,2,1,0,0,144,0.005,-3,0,0 .,2,2,27286.33043,4547.72,0,0,0,1,4 .,2,2,0,0,6,920,6.82437367,0,0 .,2,2,0,0,24,46,3.828641396,0,0 .,2,2,0,0,48,0.93,-0.072570693,0,0 .,2,2,0,0,72,0.23,-1.46967597,0,0 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