Dear all,

We wish to announce a senior-level position (Sr. Scientist to Director) in the 
Clinical Pharmacology Modelling and Simulation (CPMS) group of GlaxoSmithKline 
(GSK) in Shanghai.

GSK provides a supportive environment for scientists who are aspired to learn, 
to contribute and to make impact on business decisions through innovation. The 
position level for a successful candidate will be based on the person's skills 
and experience. As a member of our global CPMS department, you have the 
opportunities to work as the clinical pharmacology lead for China and global 
development/registration projects.

Below are the responsibilities and qualifications for the position. If 
interested, please send your CV to:<>.

Peiming Ma

Responsibilities may include:

  *   Contribute, as a member of a multi-discipline team, to the design of an 
efficient clinical development program and a robust registration package
  *   Play a central role in predicting human dose range, characterizing 
dose-response relationship and justifying dose recommendations for special 
  *   Develop mathematical and statistical models to understand a disease, its 
progression, and pharmacodynamics and pharmacokinetics; conduct meta-analyses 
as appropriate to maximize data use; conduct simulations to assess trial design 
  *   Design and interpret clinical pharmacology studies, including those to 
evaluate potential effects of intrinsic and extrinsic factors on 
pharmacokinetics and pharmacodynamics
  *   Write sections of drug development and registration documents such as 
clinical trial protocols and reports, clinical investigator brochures and 
regulatory submission packages
  *   Present and defend quantitative clinical pharmacology plans and results 
through interaction and negotiation with internal governance committees and 
external regulators
  *   Innovate through working effectively with colleagues in the department 
and others such as statisticians, biologists, physicians and drug metabolism 
  *   Learn and apply emerging modelling and simulation methodologies with a 
view to enhance clinical program efficiency and investment decision quality; 
collaborate with external field-leading teams for methodology application
  *   Promote model-informed drug development approach by publishing in 
peer-reviewed journals and presenting at scientific conferences

Basic and preferred qualifications are:

  *   Advanced training with a degree such as PhD, PharmD and MD to enable a 
successful career in quantitative clinical pharmacology in pharmaceutical 
research and development
  *   Knowledge of, or ability to quickly learn, the mechanism, endpoints, 
progression and treatments of relevant diseases
  *   Understanding of pharmacokinetic and pharmacodynamic principles and 
commonly applied models; working knowledge of common tools for quantitative 
clinical pharmacology such as NONMEM, R, WINNONLIN, Simcyp, SAS and MATLAB
  *   Experience in designing, analyzing and reporting clinical studies, with a 
simulation- or modelling-based approach where appropriate
  *   Familiarity with regulatory submission documents such as CTAs, INDs, 
NDAs, MAAs and BLAs
  *   Ability to communicate clearly and succinctly with the audience in mind, 
both orally and in writing
  *   Ability to build effective collaboration while taking personal 
accountability for delivery of quantitative clinical pharmacology results
  *   Sound judgement, analytical mindset and problem-solving skills
  *   Ability to effectively multi-task and deliver results on time

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