Hi Bob, You may find the “finedata” program in the /util subdirectory convenient for this purpose. It was introduced with v7.3 and expanded in v7.4.
Cheers… Brian From: [email protected] [mailto:[email protected]] On Behalf Of Bob Leary Sent: Friday, May 04, 2018 11:02 AM To: Leonid Gibiansky; [email protected] Subject: RE: [NMusers] Cmax/Tmax in the DES block One of the problems with all of this is that the user must manually enter artificial time points (or at least in 2007 had to do this - I don't know if this has been fixed in The latest NM versions) in the data set in order to evaluate the fitted model over more grid points than are in the original data. To get a fine grid and good resolution on Cmax and Tmax You have to enter a lot of extra time points., which is a pain in the neck. The various ODE routines are also remarkably sensitive to how the grid is set up. Much better would be to have a grid generator within NMTRAN that lets you just specify beginning and end points and number of points in the grid. I would point out that Phoenix NLME PML has always had this capability. Bob Leary -----Original Message----- From: [email protected]<mailto:[email protected]> <[email protected]<mailto:[email protected]>> On Behalf Of Leonid Gibiansky Sent: Thursday, May 3, 2018 7:59 PM To: [email protected]<mailto:[email protected]> Subject: [NMusers] Cmax/Tmax in the DES block Interesting experience concerning computation of Cmax and Tmax (and probably other stats) in the DES block. We used to use this way: http://cognigencorp.com/nonmem/current/2007-December/4125.html<http://cognigencorp.com/nonmem/current/2007-December/4125.html> Specifically, reserved the place in the memory: $ABB COMRES=2 Set these values to zero for each new subject: $PK IF(NEWIND.LE.1) THEN COM(1)=0 COM(2)=0 ENDIF and computed Cmax/TMAX as $DES IF(CONC.GT.COM(1)) THEN COM(1)=CONC COM(2)=T ENDIF $ERROR CMAX=COM(1) TMAX=COM(2) Recently I applied the same procedure to compute Cmax following 1 hr IV infusion. Unexpectedly, Tmax was estimated at times > 1 hr, and Cmax was higher than 1-hr concentration (true Cmax is at 1 hr). After some experiments, the explanation was that Nonmem computes concentration-time course (with infusion ON) for longer than 1 hr, and resulting Cmax/Tmax are at the end of the "computation window" rather than at 1 hr. Turns out that the results also depend on ADVAN routine. The largest deviation (still small, 1-3 percents) was for ADVAN8, ADVAN9, and ADVAN13. ADVAN15 was better but still off. ADVAN14 was almost perfect but still slightly (0.01%) off. ADVAN6 provided correct answer (up to the precision of the output). So, the discrepancy is small but if 1-2% difference is important, one has to be careful when using DES block computations. Thanks Leonid NOTICE: The information contained in this electronic mail message is intended only for the personal and confidential use of the designated recipient(s) named above. This message may be an attorney-client communication, may be protected by the work product doctrine, and may be subject to a protective order. As such, this message is privileged and confidential. If the reader of this message is not the intended recipient or an agent responsible for delivering it to the intended recipient, you are hereby notified that you have received this message in error and that any review, dissemination, distribution, or copying of this message is strictly prohibited. If you have received this communication in error, please notify us immediately by telephone and e-mail and destroy any and all copies of this message in your possession (whether hard copies or electronically stored copies). Thank you. buSp9xeMeKEbrUze <br /><br /> ICON plc made the following annotations. ------------------------------------------------------------------------------ This e-mail transmission may contain confidential or legally privileged information that is intended only for the individual or entity named in the e-mail address. If you are not the intended recipient, you are hereby notified that any disclosure, copying, distribution, or reliance upon the contents of this e-mail is strictly prohibited. If you have received this e-mail transmission in error, please reply to the sender, so that ICON plc can arrange for proper delivery, and then please delete the message. Thank You, ICON plc South County Business Park Leopardstown Dublin 18 Ireland Registered number: 145835
