Merck is seeking one creative, motivated Pharmacometrician to join its Pharmacometric team at Darmstadt headquarter (Germany). To apply please visit the careers pages on https://career012.successfactors.eu/career?company=merckgroup and enter the Requisition ID: 181023 or click the link below https://www.merckgroup.com/en/careers/jobs/181023
A career is an ongoing journey of discovery: our 52,000 people are shaping how the world lives, works and plays through next generation advancements in healthcare, life science and performance materials. For 350 years and across the world we have passionately pursued our curiosity to find novel and vibrant ways of enhancing the lives of others. Your role: One of your main tasks is the global support of the Quantitative Pharmacology department within Global Early Development. You provide M&S input into Clinical Development Plans and participate to sound translational science, from animal to healthy subjects, to patients, to special populations. Furthermore you plan, perform, interpret, present, track and record M&S-related activities within allocated projects and studies. Your tasks include developing of internal expertise in advanced population PKPD modeling, with emphasis on physiological and mechanistic approaches. You Keep up-to-date with scientific development in M&S, and regulatory guidance and trends. You explore, evaluate and implement appropriate pharmacometric tools and methodologies; participate to the improvement of the M&S processes and technological platform. In your function as Pharmacometrician (m/f) you will represent the whole of Quantitative Pharmacology in transactions with internal and external stakeholders. Who you are: * Master or PhD in Clinical Sciences related disciplines (Medicine, Physiology, Pharmaceutical Sciences, etc) and strong expertise in Pharmacometrics/biostatistics. Alternatively, degree in Mathematics/Statistics and strong experience in clinical development with 3+ years' experience in PKPD Modeling, of which 1+ in BioPharmaceutical Industry and knowledge of PKPD M&S input into drug development * Good command of NONMEM and R is an absolute prerequisite, experience with MONOLIX is an asset. * Experience with PsN and Xpose is an asset; as well as experience with Clinical Trial Simulation tools, alike for other analytical/modeling/optimization/presentation software or language, e.g. ADAPT, SAAM II, BERKELEY MADONA. Also experience in writing and using PKPD models, particularly mechanistic-models and in developing disease progression models is an asset. * Fluent in written and oral English and fluency in other European languages, particularly French or German, is an asset. * Strong problem solving skills and ability to analyze complex problems. * Interest in, and knowledge of, both mathematical and (patho-)physiological aspects of M&S in drug development. * Enthusiastic, self-motivated and has good communication skills, and at ease in working in a dynamic matrix organization; is a team-player. Communicate technical details effectively with scientists and clinicians colleagues. What we offer: With us, there are always opportunities to break new ground. We empower you to fulfil your ambitions, and our diverse businesses offer various career moves to seek new horizons. We trust you with responsibility early on and support you to draw your own career map that is responsive to your aspirations and priorities in life. Join us and bring your curiosity to life! Curious? Apply and find more information at come2merck.com With best regards, Akash Khandelwal, Associate Director, Local Head of Pharmacometry (Darmstadt) Pascal Girard, Senior Scientific Director, Global Head of Pharmacometry This message and any attachment are confidential and may be privileged or otherwise protected from disclosure. If you are not the intended recipient, you must not copy this message or attachment or disclose the contents to any other person. If you have received this transmission in error, please notify the sender immediately and delete the message and any attachment from your system. Merck KGaA, Darmstadt, Germany and any of its subsidiaries do not accept liability for any omissions or errors in this message which may arise as a result of E-Mail-transmission or for damages resulting from any unauthorized changes of the content of this message and any attachment thereto. Merck KGaA, Darmstadt, Germany and any of its subsidiaries do not guarantee that this message is free of viruses and does not accept liability for any damages caused by any virus transmitted therewith. Click http://www.merckgroup.com/disclaimer to access the German, French, Spanish and Portuguese versions of this disclaimer.
