Global Head of Drug Metabolism and Pharmacokinetics (DMPK)
GlaxoSmithKline
USA - Pennsylvania - Upper Providence
UK - Stevenage
Tres Cantos
SEE:
https://www.gsk.com/en-gb/careers/<https://urldefense.proofpoint.com/v2/url?u=https-3A__www.gsk.com_en-2Dgb_careers_&d=DwMGaQ&c=jqQLr8Vjrh9vQZQBMH8t0g&r=ySOb5FWtD_f91znXD7gQYQtPh-qC-wMwIR9nKeMM034&m=zVOlWBpK8TOFcgrrLyeUBLvg9RlLKnUH-R2BfJQK7W0&s=UwoHtFs_POCRuRT_L3_9nzx57G6Rn-tZEsZe2rejvYc&e=>
(posting # 194716, or you can search by "DMPK").
As the VP, DMPK you will provide single point accountability for developing and
embedding a unified and integrated global DMPK vision and strategy to ensure
the delivery of consistent, reusable DMPK data supporting the efficient and
effective progression of Discovery and Development projects, inclusive of
Research, Oncology and Global Health. This integrated global strategy will
require a focus on leadership, science, technology and culture. Reporting to
the SVP, In Vitro/In Vivo Translation, IV/IVT provides expertise in nonclinical
models, bioimaging, DMPK, bioanalysis, biomarkers, immunogenicity, safety, and
drug disposition in support of nonclinical and clinical studies spanning target
identification through post-approval of medicines.
As the VP, DMPK you will be integral in taking forward what has already been
done with regards to the new structure and look to operationalise and develop
the ways of working for this newly consolidated group. You will be responsible
for ensuring the organisation is future-proofed and look at ways to modernise,
including the greater use of technology and automation.
You will also be tasked with developing DMPK scientific experts to define the
appropriate data requirements required by projects and influence progression,
decision making, and regulatory approvals. These data sets are essential for
lead optimization, candidate selection, human pharmacokinetic and dose
prediction, as well as clinical drug-drug interactions and dose adjustment for
special populations. In this role you will need to build and maintain strong
relationships with a number of internal stakeholders including the Research
Units, Medicinal Chemistry, Product Development & Supply, and Data &
Computational Sciences, Clinical Pharmacology and Experimental Medicine,
Development and Regulatory Affairs, as well as with external organisations
(academic, CROs, technology firms).
You will be required to provide scientific and managerial leadership to an
experienced global DMPK function (c. 100 FTEs) spanning the US, UK and Spain,
to ensure best practice, focused decision making, execution of key deliverables
including the implementation of innovative technologies and approaches to
enhance scientific impact and drive efficiency, enhance the depth and breadth
of key technical skills focused on project delivery and to develop DMPK
scientists at all levels to retain and attract talent.
Responsibilities:
*Develop a unified vision and strategy for the Global DMPK function in support
of R&D objectives
*Develop and implement DMPK scientific strategies (including PBPK, PKPD) to
deliver earlier robust human PK and dose estimates and to appropriately
characterize drug Absorption, Distribution, Metabolism, and Elimination (ADME)
*Develop and implement outsourcing strategies to meet programme and project
needs
*Provide scientific and managerial leadership to a global DMPK function to
ensure execution of key deliverables to the entire R&D portfolio with effective
people and capital resource allocation across sites
*Implement innovative technologies and approaches to enhance scientific impact
and drive efficiencies
*Build strong collaboration and effective interfaces with all Research Units,
Medicinal Science & Technology (especially Medicinal Chemistry, Product
Development & Supply, and Data & Computational Sciences), other lines within
IVIVT, Clinical Pharmacology and Experimental Medicine, Development and
Regulatory Affairs, as well as with external organizations (academic, CROs,
technology firms).
*Ensure timely completion of DMPK contributions to internal dossiers and
regulatory submissions
Technical Skills & Experience
*PhD or equivalent in Drug Metabolism and Pharmacokinetics or related discipline
*Knowledge of Discovery and Development DMPK. Ability to assess drug
developability
*Significant experience in drug discovery and development with a deep
scientific and strategic expertise in cross functional interdependencies.
*Track record in leading a multidisciplinary DMPK function.
Competencies
*Proven ability to influence, communicate and negotiate with all levels of
management across functional and business unit boundaries
*Excellent oral & written communication and presentation skills
*High mental and people agility
*Ability to build strong relationships across broad stakeholders.
*Design and implement a plan to recruit, develop and retain key talent to
maintain a high-performing team
GSK monitors email communications sent to and from GSK in order to protect GSK,
our employees, customers, suppliers and business partners, from cyber threats
and loss of GSK Information. GSK monitoring is conducted with appropriate
confidentiality controls and in accordance with local laws and after
appropriate consultation.
