Dear colleagues, We have an interesting position available for a Scientist Quantitative Pharmacology at Genmab's global R&D center in Utrecht, the Netherlands. The job details are below. Follow one of these links to apply: Scientist Quantitative Pharmacology | Genmab | LinkedIn<https://www.linkedin.com/jobs/view/2330412867/?refId=sGFe4qc6jLtRnZvnuiQlVQ%3D%3D&trackingId=8vT52pj5%2FIM2ppW1mYs33w%3D%3D> Scientist Quantitative Pharmacology (myworkdayjobs.com)<https://genmab.wd3.myworkdayjobs.com/en-US/Genmab_Careers_Site/job/Utrecht/Scientist-Quantitative-Pharmacology_R866>
Our team will also be expanding in Princeton (NJ) with openings in Clinical and Quantitative Pharmacology and QSP modeling. Check www.genmab.com or LinkedIn for more information. #### Genmab is focused on the creation and development of innovative and differentiated antibody products, with the aim of improving the lives of cancer patients. Role The Quantitative Pharmacology Scientist will provide pharmacology expertise to programs through all stages of research and development. The person will contribute to the design of non-clinical studies and will be responsible for interpretation and reporting of pharmacokinetics, toxicokinetics and pharmacodynamics of drug candidates. This individual will help generate an in-depth understanding of all aspects of PK and PD of Genmab's next generation antibody technologies by building and refining platform quantitative system pharmacology models, and applying these models to guide rational experimental designs and critical decisions on candidate antibody therapies. In this role they will also work on the execution of pre-clinical and clinical development programs in close collaboration with scientists in Translational Research and Clinical Development, conducting quantitative PK/PD/safety/efficacy analyses for integration into overall program strategies. They will provide rationale for dose regimen selection in first in human (FIH) trials and beyond, and identification of circumstances where dose adjustment or patient selection/stratification should be considered. This is an exciting opportunity to be part of a passionate, high profile, high-impact Pharmacology team, and to work in a highly dynamic and collaborative setting, with opportunities for professional development. Responsibilities * Provides pharmacology support to multi-disciplinary study teams for pre-clinical and clinical programs. * Contributes expert pharmacology input into key pre-clinical, clinical, and regulatory documents including study protocols, study reports, investigator brochures, and other documents within agreed timelines. * Assumes responsibility for TK, PK and PD evaluation and reporting in assigned non-clinical studies. * Contributes to building and refining platform quantitative system pharmacology models to generate in-depth understanding of PK/PD characteristics of proprietary antibody technologies. * Helps define and execute PK/PD modeling and simulation plans to guide rational first in human dose projection and dose selection. * Leads clinical pharmacology efforts (e.g., study design, protocol concepts/protocols preparation, clinical phase oversight, data analysis, and reporting) within assigned programs to yield high value PK/PD insight for critical decisions. * Analyzes results, interprets, and recommends action based on study results. * Performs PK and PK/PD analyses using a variety of tools and approaches. * Integrates, interprets, and reports data to project teams and other customers. * Serves on Global Pre-Clinical and Clinical Development Teams and provides a source of Pharmacology expertise and advice to other functions across Genmab. * Performs other responsibilities as requested by management. Requirements * A PharmD or PhD in Clinical Pharmacology, Pharmacology, Pharmacokinetics, or related discipline is required. * Approximately 0-2 years of experience in pre-clinical and/or clinical pharmacology in pharma, biotechnology, or consulting. * Experience with noncompartmental PK analysis, allometric scaling, analysis of pre-clinical and/or clinical PK/PD data is also required. * Affinity for quantitative methods and demonstrated ability to apply modeling and simulation approaches to pre-clinical and clinical drug development are required. * Hands-on experience with programming in R is highly desired. * Experience with application of quantitative tools such as WinNonLin/Phoenix, NONMEM, and/or other PK/PD analysis software is preferred. * An understanding of antibody therapeutics development and experience in the field of oncology or immunology are considered beneficial. * Flexible, with a positive and proactive attitude, ability to work with multidisciplinary teams, prioritize projects effectively and communicate at all levels within the company. * Excellent written, verbal, and interpersonal communication skills. In case you have any questions, please feel free to reach out to Recruiter Mark Stickland at [email protected]<mailto:[email protected]> Genmab employees work with determination and with respect for each other, consistent with our core values, to achieve our common goals. We give individuals and teams the autonomy to drive development of innovative products and solutions, knowing that integrity is a core value throughout our company. Genmab will offer the successful application a challenging position, where the right candidate will have the opportunity to work with highly specialised people across functions in an informal, multicultural culture, all aiming to make a difference for cancer patients. Teamwork and respect are central pillars of Genmab's culture and we therefore ensure an inclusive, open, and supportive professional work environment across our international locations. We believe that fostering workplace diversity across social, educational, cultural, national, age and gender lines is a prerequisite for the continued success of the company. We are committed to diversity at all levels of the company and strive to recruit employees with the right skills and competences, regardless of gender, age, ethnicity, etc. Please note that if you are applying for a position in the Netherlands; Genmab's policy for all permanently budgeted hires in this location is to offer a temporary agreement for one year, followed by a contract for indefinite time regardless of seniority. Genmab A/S is committed to protecting your personal data and privacy. Please see our privacy policy for handling your data in connection with you application on our website https://www.genmab.com/privacy. * Apply
