[NMusers] Assessment of elimination half life of mAb

[Niurys.CS]

Dear all
I need some help to assess the elimination half life of a monoclonal
antibody.
The model that describes the data is a QSS aproximation of TMDD with Rmax
constant. The model includes two binding process of mAb to its target: in
central and peripheral compartments.
Is there any specific equation to calcule lambda z and the elimination half
life for each of the TMDD aproximations?
Thanks
Niurys