yes, it does at estimation, not sure about simulations step.
If you need true exponential error, log-transform of DV and model
predictions is needed
Leonid
On 7/19/2021 11:34 AM, Guidi Monia wrote:
Dear colleagues,
We would like to compare the NONMEM predictions with those obtained by a
Bayesian TDM software for models describing the residual unexplained
variability with exponential errors.
We need to know if NONMEM performs a first order Taylor expansion of the
exponential error when data are fitted by the FOCE method:
Y=F*EXP(EPS(1)) -> Y= F*(1+EPS(1)).
Could someone help with this?
Thanks in advance
Monia
Monia Guidi, PhD
Pharmacometrician
Service of Clinical Pharmacology | University Hospital and University of
Lausanne
Center of research and innovation in Clinical Pharmaceutical Sciences |
University Hospital and University of Lausanne
BU17 01/193
CH-1011 Lausanne
email: monia.gu...@chuv.ch <mailto:monia.gu...@chuv.ch>
tel: +41 21 314 38 97
*CHUV**
**_centre hospitalier universitaire vaudois_*
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