Hi Roeland,
ERROR_TERM in Y and in DUM should differ: one should include EPS() while
the other should use only SD. F_FLAG should be set to zero outside M3
block. What is DRUG.EQ.1, is it parent? there should be a separate M3
part for metabolite.
It would be easier to debug if you would provide the full code of the
ERROR block
Thank you,
Leonid
On 8/16/2022 6:53 AM, Roeland Wasmann wrote:
Hi all,
I have a problem while trying to implement the m3 method in my model
with a parent and metabolite. I could really use some help.
About 50% of the parent data is BLQ while the metabolite only has a
couple of BLQs. When modeling them separately there is no issue but when
I have them both in one model, I get the following error:
/Recompiling certain components.
starting wait
ending wait
Exiting lpreddo
Compiling FSUBS
FSUBS.f90:1322:6:/
/ B000056=PHI(DUM)/
/ 1/
/Error: Unclassifiable statement at (1)
Building NONMEM Executable
gfortran: error: fsubs.o: No such file or directory
No nonmem execution.
It seems like Fortran compilation by NONMEM's nmfe script failed. Cannot
start NONMEM.
Go to the NM_run1 subdirectory and run psn.mod with NONMEM's nmfe script
to diagnose the problem./
The NM_run1 folder does not provide any answers… The M3 part of the
error block looks like this:
Y = IPRED + ERROR_TERM
*DUM = (LLOQ-IPRED) / ERROR_TERM
CUMD = PHI(DUM)
IF (ICALL.NE.4.AND.BLQ.GT.0.AND.DRUG.EQ.1) THEN
F_FLAG = 1
Y = CUMD
MDVRES = 1
ENDIF*
When I put the “DUM” part within the PHI (i.e., “*CUMD =
PHI(((LLOQ-IPRED) / ERROR_TERM))*” the error changes slightly:
/Compiling FSUBS
FSUBS.f90:1324:6:/
/ B000058=PHI(B000056)/
When I remove the “*.AND.DRUG.EQ.1*” from IF I get:
/FSUBS.f90:1355:6:/
/ B000061=PHI(DUM)/
Please let me know what info I should provide to better diagnose this
problem challenge.
Thanks in advance for helping out!
Cheers Roeland
------------------------------------------
*Roeland Wasmann, PharmD, PhD*
Division of Clinical Pharmacology
Department of Medicine
University of Cape Town
K45 Old Main Building
Groote Schuur Hospital
Observatory, Cape Town
7925 South Africa
phone: +27 21 650 4861
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