Hi,
I'm not sure why the error is only for positive DV, but the error message is stating that it is only looking for positive (and not nonzero) values. Since DV is negative on row 12, you're not getting the warning. More generally for NONMEM, you should have your observations on different rows than doses. So, all of those rows should have DV set to "." (or equivalently "0"), and insert a new row with the DV measurement on it for estimation. Thanks, Bill From: [email protected] <[email protected]> On Behalf Of [email protected] Sent: Monday, September 5, 2022 10:41 AM To: [email protected] Subject: [NMusers] data All: I have data which looks like this with the line number inserted in ( ). WSUBJ TIME CP MDV CTIME DAY AMT EVID DV (1)1 0 0 0 0 1 0.001 1 0.153846 (12)2 0 0 0 0 1 0.001 1 -0.30769 (21)3 0 0 0 0 1 0.001 1 1.076923 I get the following warning with each run. (DATA WARNING 5) RECORD 1, DATA ITEM 9, CONTENTS 0.1538 THE DV DATA ITEM IS POSITIVE, BUT THE MDV ITEM IS 1 (DATA WARNING 5) RECORD 21, DATA ITEM 9, CONTENTS 1.0769 THE DV DATA ITEM IS POSITIVE, BUT THE MDV ITEM IS 1 Each is a dosing for PD; however, it does not happen for record 12, also a dosing record. Can someone tell me why, and how to address this issue?
