Thank you, Bob!
Ctl-T command is not working in parallel mode (on my Windows 10 system)
but it worked perfectly fine in the single-processor mode.
Thank you
Leonid
On 9/16/2022 5:21 PM, Bauer, Robert wrote:
Leonid:
You can enter ctrl-T to see OFV outputs of each subject, and you can
note which of the subjects is issuing an LNV1PD: 129 error. The error
issues first, then the subject number is shown.
Robert J. Bauer, Ph.D.
Senior Director
Pharmacometrics R&D
ICON Early Phase
731 Arbor way, suite 100
Blue Bell, PA 19422
Office: (215) 616-6428
Mobile: (925) 286-0769
[email protected] <mailto:[email protected]>
www.iconplc.com <http://www.iconplc.com>
-----Original Message-----
From: [email protected] <mailto:[email protected]>
<[email protected]> On Behalf Of Leonid Gibiansky
Sent: Friday, September 16, 2022 12:57 PM
To: nmusers <[email protected]>
Subject: [EXTERNAL] [NMusers] Continuation of "What does "Second Error
signal from LINV1PD: 129"
Hi Nick and Bob,
There was a thread in 2010 about LINV1PD: 129 error, see below.
Is it possible to get ID(s) of the subject(s) with the problem or
extract any other useful information to debug the issue? I am using
ADVAN5 with LAPLACIAN option (with PROTECT), are there any tricks that
would help to avoid or debug the problem? The iterations move forward in
spite of multiple error messages that continue to appear through the
whole run, and the model provided the parameters and predictions, and
even completed the covariance step but it would be helpful to find out
what causes the error.
Thank you
Leonid
===================================================================
Nick:
It means that a positive definiteness correction on the eta Hessian
matrix of a particular individual at a particular iteration was not
successful, but NONMEM goes ahead anyway. If it happened on an
intermediate iteration, and the error signal was not continually
repeated, then NONMEM managed to get through the numerical rough spot,
and there is not likely a systematic issue to the problem.
Robert J. Bauer, Ph.D.
______________________________
Sent: Friday, November 19, 2010 7:16 PM
To: nmusers
Subject: [NMusers] What does "Second Error signal from LINV1PD: 129"
mean?
Hi,
I'm using NM7.1.2
$EST MAX=9990 NOABORT NSIG=3 SIGL=9 PRINT=1 METHOD=CONDITIONAL LAPLACIAN
SLOW $SUBR ADVAN6 TOL=6 Predictions are made using F_FLAG=0 and F_FLAG=1
I get this message I have never seen before. It happens with one
particular model that is closely related to others that run Ok. The
model with this error seems to run Ok and produces plausible parameters.
What does this message mean?
Second Error signal from LINV1PD: 129
Nick
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