The nlmixr2/rxode2 team is excited to announce a tool to help conversion of NONMEM to rxode2 or nlmixr2 fits with nonmem2rx and babelmixr2.
With nonmem2rx/babelmixr2 you can do many useful tasks directly converting between nlmixr2 and NONMEM models; you - Convert a NONMEM model to a rxode2 model - Do development in nlmixr2 and then run NONMEM from a nlmixr2 model for reviewers who want to know about NONMEM results. - In both conversions, automatically make sure the model is translated correctly Then with nlmixr2 fit models coming from both conversions, you can: - Perform simulations of new dosing from the NONMEM model or even simulate using the uncertainty in your model to simulate new scenarios - Modify the model to calculate derived parameters (like AUC). These parameters slow down NONMEM’s optimization, but can help in your simulation scenario. With nonmem2rx and babelmixr2, convert the imported rxode2 model to a nlmixr2 object, allowing: - Generation of Word and PowerPoint plots with nlmixr2rpt - Easy VPC creation (with vpcPlot()) - Easy Individual plots with extra solved points. This will show the curvature of individual and population fits for sparse data-sets (with augPred()) You can even use this conversion to help debug your NONMEM model (or even try it in nlmixr2 instead) - Understand how to simplify the NONMEM model to avoid rounding errors - Run nlmixr2’s covariance step when NONMEMs covariance step has failed For more details talk to us at our PAGE poster, read our blog or our websites: https://blog.nlmixr2.org/blog/2023-06-02-nonmem2rx-and-babelmixr2/ https://nlmixr2.github.io/nonmem2rx/ https://nlmixr2.github.io/babelmixr2/
