Dear Mohd, Do you need METHOD=1 (COND) under $Estimation when you use LAPLACIAN?
I could be wrong, but just remove it and leave for defaults. Thank you, Simba On Sat, Mar 23, 2024, 4:56 PM Mohd Rahimi <rahimi1...@gmail.com> wrote: > Dear NONMEM user, > > I tried to run a VPC for M2 BQL method by using the code as stated below: > > ;M2 - Likelihood assumes all values are censored at LLOQ ‘YLO’ > > > > > > > > > * SD = SQRT(1 + THETA(4)**F**2) YLO=LOG(LLOQ) IPRED=F W=SD IRES = > DV-IPRED IWRES = IRES/W Y = F + SD*EPS(1)* > > > *$ESTIMATION METHOD=COND LAPLACIAN INTER NUMERICAL NOABORT SLOW NSIG=2 > SIGL=9 MAXEVAL=9999 PRINT=1* > > But I got this kind of error message from NONMEM > > > > * AN ERROR WAS FOUND IN THE CONTROL STATEMENTS. 585 LAPLACIAN METHOD IS > REQUIRED WHEN YLO, YUP, CTLO, OR CTUP IS USED.* > > Any thoughts on how to solve this? > > Thank you > > -- > *Mohd Rahimi Muda* >
