This is a generic error message, nothing informative except indicates
that there are some numerical problems.
You can try to change ADVAN (6 to 13, if this is differential equations
model) or TOL on $SUBR record, SIGL and NSIG on $EST, change initial
conditions to the values of the previous model (assuming that there was
some model) or to a realistic range. Sometimes MCETA=1000 on $EST recods
helps with this message. Often this is related to the outliers, so it
helps to clean the data. One can try to increase initial values of
$SIGMAs or add random effect on the residual error.
If this is a complex model, you may try to start with something simple,
like linear, and use the output as initial parameters, and also look for
outliers (very large CWRES).
Thank you
Leonid
On 9/18/2024 8:09 AM, Sébastien Bihorel wrote:
Hi Marie,
Can you please share your $ERROR block?
Thanks
------------------------------------------------------------------------
*From:* owner-nmus...@globomaxnm.com <owner-nmus...@globomaxnm.com> on
behalf of Marie Rajerison <marie.rajeri...@corteriapharma.com>
*Sent:* Wednesday, September 18, 2024 5:22 AM
*To:* nmusers@globomaxnm.com <nmusers@globomaxnm.com>
*Subject:* [External] [NMusers] 0PRED EXIT CODE = 1
Dear NM users, I have often noticed the following error message on NM
chat but I have never really found a concrete solution to resolve it. I
might have missed it. Can anyone advise how to fix this error? 0PRED
EXIT CODE = 1 0INDIVIDUAL NO.
Dear NM users,
I have often noticed the following error message on NM chat but I have
never really found a concrete solution to resolve it. I might have
missed it.
Can anyone advise how to fix this error?
0PRED EXIT CODE = 1
0INDIVIDUAL NO. 4 ID= 4.00000000000000E+00 (WITHIN-INDIVIDUAL)
DATA REC NO. 2
THETA=
1.00E-03 5.00E-01 1.00E+01 1.00E+01 1.00E-01 1.00E+01
1.00E+00
OCCURS DURING SEARCH FOR ETA AT INITIAL VALUE, ETA=0
F OR DERIVATIVE RETURNED BY PRED IS INFINITE (INF) OR NOT A NUMBER (NAN).
Elapsed estimation time in seconds: 0.00
Thank you in advance for your help
Marie
*Marie RAJERISON*
*PharmD PhD*
*Pharmacometrician*
*e-mail: marie.rajeri...@corteriapharma.com
<mailto:marie.rajeri...@corteriapharma.com>*
128 rue de la Boetie
75008 Paris
France
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