Depends on which APIs you want to interact with.

Many COM and .NET APIs can be dynamically bound to. 

On Jul 9, 2012, at 3:45 PM, mscdex wrote:

> On Jul 9, 1:23 pm, AaronNGray <[email protected]> wrote:
>> I am interested whether anyone has created bindings for any of the MS
>> Windows API ?
> 
> This would be quite an undertaking for a generic binding. There is
> node-ffi, but AFAIK that's not recommended for production use because
> of the performance penalties.
> 
> Your best bet is to incorporate just the Windows API functions you
> need for your binding/project.
> 
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