To the original question, as confirmed by others ExtJS and node will work 
fine.  I have used extJS in the past, ended up moving on from it so I 
thought I would post about my experience.  Basically, I found it to be a 
very heavy weight client side framework  - does a lot of things for you, 
but makes a lot of decisions that you might have wanted to do differently. 
 I was disappointed in the GUI generator -- at the time it appeared to have 
some bugs or limitations, and I ended up having to ditch it and write my 
own javascript code, in the framework that ExtJS wanted.  All of this made 
me think that maybe instead of trying to hide my CSS inabilities I ought to 
buckle down and just learn it better.  

I've now switched to a much lighter-weight assemblage of client side tools 
that I am quite happy with: Backbone.js (view and data handling), jQuery 
(of course), jQuery data tables (a fine replacement for extJS data grids), 
bootstrap CSS, and an additional bootstrap CSS template with lots of ready 
to use widgets (
http://themeforest.net/item/katniss-premium-admin-template/3878281).  On 
the server side, the usual: node, express, jade.  I'm using mongodb for the 
database; could of course be a SQL database but boy oh boy is implementing 
the database layer a lot easier in mongodb.

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