I know this is an old thread, but if anyone is looking for more help with 
doing direct IO in Node.js, we released a native add on yesterday which 
provides helpers for things like O_DIRECT, O_SYNC, O_DSYNC, aligned 
buffers, F_NOCACHE on macOS, FSCTL_LOCK_VOLUME on Windows etc.

https://github.com/ronomon/direct-io

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