jujiale opened a new issue, #8166:
URL: https://github.com/apache/apisix/issues/8166

   ### Description
   
   hello:
    we have two apisix env(such as A and B),  when we use apisix to proxy grpc 
service,  A always OK, but in B, when you first time send a request. It returns 
502, but the following request all returns 200. and I also found that when we 
send a request in B, after a while,send request again, then the first request 
always return 502, the following return 200. I am confused of such thing. 
because A and B env apisix version and depends are same. 
     
    when 502 occurs. the following error occurs:
   `
   
       [error] 20620#20620: *327238 no connection data found for keepalive 
http2 connection while sending request to upstream
   
   `
   
   I want to get some idea from you.  what causes it and how to solve it. 
   hope yours. thanks.
   
   ### Environment
   
   - APISIX version (run `apisix version`): v2.12.0
   - Operating system (run `uname -a`): the problem env is :Linux 
3.10.0-1160.36.2.el7.x86_64. the good env is: Linux 3.10.0-957.21.3.el7.x86_64
   - OpenResty / Nginx version (run `openresty -V` or `nginx -V`): nginx 
version: openresty/1.21.4.1
   - etcd version, if relevant (run `curl 
http://127.0.0.1:9090/v1/server_info`): 3.5.0
   - APISIX Dashboard version, if relevant:
   - Plugin runner version, for issues related to plugin runners:
   - LuaRocks version, for installation issues (run `luarocks --version`):
   


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