I've been dealing with that same error message for a few weeks, affecting just one user. Windows 7 Pro x64, Office 2013 32bit. The only difference with this user is that she has Quickbooks 2013 installed, which does have some kind of Outlook plugin. Same exact error message you are getting. I believe she sees that message either at boot up or every time she launches Outlook.
From: [email protected] [mailto:[email protected]] On Behalf Of Rick Berry Sent: Friday, March 14, 2014 12:27 PM To: [email protected] Subject: [NTSysADM] ie10 send link as email fails, sbs interference? User with Office 2013 H&B 32bit + IE10 on Win7 Pro x64 ... all new machines. On their old machines (mix of 7 and office 7/10) the send/link by email or page by email function used to work. Now they get: "Either there is no default mail client or the current mail client cannot fulfill the messaging request. Please run Microsoft Outlook and set it as the default mail client." But it already is set that way. I google-fu'ed it and didn't really come up with much, but did notice that when I tried to unset everything in the control panel for Default Programs I couldn't uncheck any boxes for any default programs (was going to uncheck them all and then recheck them all for Outlook). Suspect possible SBS involvement here, they do have a R2 SBS 2011 box, wondering if anyone has run across similar and knows how to perhaps set outlook as the default mail client at the SBS level. Not sure if it's an Office 2013 vs. SBS 2011 gpo defaults/etc. Found one link on setting outlook as a default mail client via GPO, but wasn't SBS specific nor was it intended for office 2010 or 13. http://support.microsoft.com/kb/2008044?ppud=4&wa=wsignin1.0 Feel like I'm dancing around the problem without finding the fix, but close to it?

