No issues, you can create an msi with the tuner that allows you to specify the 
default app that opens pdf's in that scenario.

From: Paul Hutchings [mailto:[email protected]]
Sent: Wednesday, August 03, 2011 1:40 PM
To: NT System Admin Issues
Subject: Acrobat X Reader via GPO/MSI?

We currently deploy Reader 9.x via GPO/MSI.  I hadn't realised that Adobe have 
released an updated customization wizard for Reader X, so now there's no reason 
that I can see not to deploy it, unless you good folks have any horror stories 
to share...

The biggest potential banana skin that I can see if if it has any issues being 
installed on a system that has an earlier (could be 9.x, 8.x or 7.x) version of 
full Acrobat installed, other than that we're pretty standard in terms of PC 
config.
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