There are several scenarios with Exchange 2010 that require IPv6 to be enabled.

Microsoft has made it clear that, with the recent operating system versions 
(2008 and 2008 r2), they are doing testing with IPv6 turned on and you MAY have 
anomalous results if it is turned off.

Regards,

Michael B. Smith
Consultant and Exchange MVP
http://TheEssentialExchange.com

From: Don Ely [mailto:[email protected]]
Sent: Tuesday, September 14, 2010 11:37 PM
To: NT System Admin Issues
Subject: Re: My first Win2008R2 Domain Server and IPv6

I don't believe anything breaks when you disable it.  In fact, you will find 
more data out there suggesting it is disabled if not in use because it causes 
odd things to happen...
On Tue, Sep 14, 2010 at 7:54 PM, Richard Stovall 
<[email protected]<mailto:[email protected]>> wrote:
Haven't there have been a number of threads here over the last year or so that 
have warned against disabling IPv6 on Server 2008 / SP1 / R2.  I haven't paid 
particularly close attention, and forgive me for posting without having all my 
ducks lined up, but aren't there some things that break by disabling IPv6?


On Tue, Sep 14, 2010 at 4:06 PM, Jim von Stein 
<[email protected]<mailto:[email protected]>> wrote:
Total 2008 Server/IPv6 noob question here:

I'm trying to bring up my first 2008 R2 domain server, and I hit a speed  bump 
with IPv6; dcpromo (at least the GUI version) won't proceed without some sort 
of IPv6 address. My ISP isn't supporting it yet, I'm not using it internally 
yet. Am I better off removing IPv6 from the interface(s) or doing a ULA (even 
though I don't know what I'm doing or what I'll eventually want to be doing).

Jim v.


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