@scottpurdy, thank you for your help, i have tried to run outside pycharm as 
your suggestion , but it is not working. 
i run “python run_mnist_experiment.py”  in shell ,  and got the same error.
> 在 2015年10月16日,23:35,Scott Purdy <[email protected]> 写道:
> 
> I'd recommend trying to run out outside pycharm. The cPickle library used in 
> the current serialization is not thread safe which may be the issue when 
> running it through pycharm. Please follow up after you try running it outside 
> pycharm.
> 
> On Oct 16, 2015 12:39 AM, "[email protected] 
> <mailto:[email protected]>" <[email protected] 
> <mailto:[email protected]>> wrote:
> hi ,Marek Otahal
>   Thank you for your help , my testing data is 120*230 images ,so i change 
> the inputWidth=27600, when i use the parameters as following:
>     "columnCount": 12288,
>     "spatialImp": "cpp",
>     "inputWidth": 27600,
>     "spVerbosity": 1,
>     "synPermConnected": 0.4,
>     "synPermActiveInc": 0.001,
>     "synPermInactiveDec": 0.0005,
>     "seed": 1956,
>     "numActiveColumnsPerInhArea": 2400,
>     "globalInhibition": 1,
>     "potentialPct": 0.4,
>     "maxBoost": 1.0
> and  i save the network ,i got the error :
> 
> Traceback (most recent call last):
>   File "/Users/tony/nupic.vision/nupic/vision/mnist/run_mnist_experiment.py", 
> line 833, in <module>
>     trainNetworkWHZ(net,netName,"mnist/whz_video")
>   File "/Users/tony/nupic.vision/nupic/vision/mnist/run_mnist_experiment.py", 
> line 405, in trainNetworkWHZ
>     net.save(networkFile)
>   File 
> "/Library/Python/2.7/site-packages/nupic-0.3.3-py2.7.egg/nupic/engine/__init__.py",
>  line 721, in save
>     engine.Network.save(self, *args, **kwargs)
>   File 
> "/Library/Python/2.7/site-packages/nupic.bindings-0.2.1-py2.7-macosx-10.9-intel.egg/nupic/bindings/engine_internal.py",
>  line 1082, in save
>     return _engine_internal.Network_save(self, *args, **kwargs)
> SystemError: NULL result without error in PyObject_Call
> Process finished with exit code 1
> 
>  I think that  maybe the parameter “columnCount" result the error,so i 
> increase columnCount to 122880, the result is what i write as the previous 
> email .
> I have send email to scott as your suggestion , and can you explain the 
> reason for the above error?  the max number of column  that i can create is ?
> thank you for your explantion 
> 
> 
> 
>> 在 2015年10月16日,13:39,Marek Otahal <[email protected] 
>> <mailto:[email protected]>> 写道:
>> 
>> large file serialization problem
> 

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