Pain is inevitable i guess. You could have a master hub which acts as
a backbone and keep track of all clients, billing and what is where
and whats its status.

And then have local hubs to store and process data in local timezones
as you expand your services. Processing could be done in local hubs
and then local hubs can communicate with the backbone to keep
everything in sync.

But to start with I guess you should not worry about the bandwidth too
much, because most traffic would be incoming, most hosts charge less
for upload bandwidth.

If you could share more about this application and its constraints
maybe someone could come up with better suggestions.

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