While I agree the easiest solution is to use Homebrew, the error message 
suggests installing pkg-config.

(This shouldn't be an error, it certainly works without pkg-config on the 
current development code: Download ZIP 
<https://github.com/openbabel/openbabel/archive/master.zip>)

-Geoff

---
Prof. Geoffrey Hutchison
Department of Chemistry
University of Pittsburgh
tel: (412) 648-0492
email: geo...@pitt.edu
web: http://hutchison.chem.pitt.edu/

> On Aug 19, 2015, at 12:17 PM, CHAO-JUNG LIU <speed8...@gmail.com> wrote:
> 
> 
> <Screen Shot 2015-08-19 at 10.27.48.png>
> 
>> On 19 Aug 2015, at 15:57, Geoffrey Hutchison <geoff.hutchi...@gmail.com 
>> <mailto:geoff.hutchi...@gmail.com>> wrote:
>> 
>>> However, I tried many times compiling it on my Mac through Cmake though, it 
>>> always failed.
>> 
>> I develop on the Mac. What exactly does "failed" mean. Can you give specific 
>> error messages?
>> 
>> Thanks very much,
>> -Geoff
>> 
> 

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