On Oct 6, 2010, at 9:42 AM, françois Bagaïni wrote:
> But When I fit the Nterminal ends of both molecules (initial conformer and 
> the result of the program), the C-terminal end is not superimposed. It looks 
> as if minimization can't deal with geometrical constraints. What's wrong in 
> my program?

Are you sure it's the minimization and not the WeightedRotorSearch call which 
has problems? I just tried what you asked in Avogadro (which uses OB for force 
fields and minimization) and I had no problems with freezing atoms for 
minimization.

I'm just not sure that the conformer search handles constraints -- and I think 
that's where your problem is.

What happens if you comment out the WeightedRotorSearch call?

-Geoff


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