Dear all,Silicos NV is pleased to announce the release of its newest open source program STRIPPER v1.0.4, built on top of the Open Babel 2.3.0 C+ + library.
STRIPPER is a program to extract the core structures, also called scaffolds, from organic drug-like molecules by 'stripping' away the sidechains. The program incorporates a number of predefined scaffold- extraction algorithmes, including the scaffolds as described by:
- Bemis & Murcko (J. Med. Chem. 1996, 39, 2887-2893)- Pollock, Coutsias, Wester & Oprea (J. Chem. Inf. Model. 2008, 48, 1304-1310) - Schuffenhauer, Ertl, Roggo, Wetzel & Koch (J. Chem. Inf. Model. 2007, 47, 47-58) [an interpretation of this work has been implemented in STRIPPER]
STRIPPER can be downloaded from Silicos' website (www.silicos.com). The program is free software and one can redistribute and/or modify it under the terms of the GNU General Public License as published the Free Software Foundation version 2 of the License.
Silicos NV is a Belgian service-based company providing services and tools in the fields of chemoinformatics, chemogenomics and database characterisation. Several other chemoinformatics tools have been brought into the open source domain by Silicos, including SIEVE, PHARAO, PIRAMID, and OBSPECTROPHORE, the latter being part of Open Babel 2.3.
For more information about STRIPPER or any other tools, please contact Silicos at i...@silicos.com.
Kind regards, Hans De Winter CSO - Silicos NV
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