On Sun, Oct 07, 2012 at 08:19:07PM +0100, Noel O'Boyle wrote:
> On 6 October 2012 16:13, Reinis Danne <[email protected]> wrote:
> > On Sat, Oct 06, 2012 at 01:06:51PM +0200, David van der Spoel wrote:
> > OB wiki SMARTS page [1] mentions that OB SMARTS implementation
> > "is known to not currently support Tetrahedral stereochemistry
> > involving a lone pair (e.g. at a sulfoxide)", but I'm not sure
> > if that is still the case. Anyhow that is an issue which can be
> > fixed.
> 
> This is still the case. Probably best to fix the SMARTS going forward
> if that indeed fixes the problem. Support for 'regular' tet stereo in
> SMARTS was only added in Nov of last year as far as I remember...

As far as bond order perception is concerned stereochemistry is
irrelevant. Connectivity information was enough to set proper SO
bond orders (see r5034). The wiki text catched my eye since I
tought there might be a smarts pattern saying [#16D3tetrahedral]
which could be used to define sulfoxide bondtypes.


Reinis

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