Hi Alessandro,
Here is the schema.

Thank you.
Regards,
Bharath
----------------------------------------------+------------------------------------+------------+----------------+
 NAME                                         | 
SUPERCLASS                         | CLUSTERS   | RECORDS        |
----------------------------------------------+------------------------------------+------------+----------------+
 _studio                                      
|                                    | 59         |              4 |
 AQ                                           | 
E                                  | 44         |         606008 |
 AUI                                          | 
V                                  | 38         |              0 |
 AUI_0                                        | 
AUI                                | 39         |        1747126 |
 AUI_1                                        | 
AUI                                | 40         |        1747277 |
 AUI_2                                        | 
AUI                                | 41         |        1747741 |
 AUI_3                                        | 
AUI                                | 42         |        1746487 |
 AUI_4                                        | 
AUI                                | 43         |        1747722 |
 CHD                                          | 
E                                  | 45         |        3411387 |
 Corpus                                       | 
V                                  | 56         |              4 |
 CUI                                          | 
V                                  | 20         |           1372 |
 CUI_0                                        | 
CUI                                | 21         |         594601 |
 CUI_1                                        | 
CUI                                | 22         |         594779 |
 CUI_2                                        | 
CUI                                | 23         |         594842 |
 CUI_3                                        | 
CUI                                | 24         |         594248 |
 CUI_4                                        | 
CUI                                | 25         |         594394 |
 Document                                     | 
V                                  | 57         |           9067 |
 E                                            
|                                    | 10         |              0 |
 ENTITY                                       | 
V                                  | 18         |             22 |
 hasCui                                       | 
E                                  | 16         |       49970218 |
 isa                                          | 
E                                  | 13         |              0 |
 LUI                                          | 
V                                  | 26         |              0 |
 LUI_0                                        | 
LUI                                | 27         |        1223326 |
 LUI_1                                        | 
LUI                                | 28         |        1223955 |
 LUI_2                                        | 
LUI                                | 29         |        1223304 |
 LUI_3                                        | 
LUI                                | 30         |        1223100 |
 LUI_4                                        | 
LUI                                | 31         |        1223541 |
 next                                         | 
E                                  | 12         |              0 |
 OFunction                                    
|                                    | 6          |              0 |
 OIdentity                                    
|                                    | -          |              0 |
 ORestricted                                  
|                                    | -          |              0 |
 ORIDs                                        
|                                    | 8          |              0 |
 ORole                                        | 
OIdentity                          | 4          |              3 |
 OSchedule                                    
|                                    | 7          |              0 |
 OTriggered                                   
|                                    | -          |              0 |
 OUser                                        | 
OIdentity                          | 5          |              3 |
 PAR                                          | 
E                                  | 46         |        3411387 |
 partOf                                       | 
E                                  | 11         |        2862764 |
 QB                                           | 
E                                  | 47         |         606008 |
 RB                                           | 
E                                  | 48         |        1401463 |
 rel                                          | 
E                                  | 17         |       25362226 |
 RELATION                                     | 
V                                  | 19         |             12 |
 RL                                           | 
E                                  | 49         |          62672 |
 RN                                           | 
E                                  | 50         |        1401463 |
 RO                                           | 
E                                  | 51         |       10493889 |
 RQ                                           | 
E                                  | 52         |         621916 |
 semantic                                     | 
E                                  | 15         |       56358706 |
 SEMANTIC_TYPE                                | 
V                                  | 55         |            138 |
 Sentence                                     | 
V                                  | 58         |        2853697 |
 SIB                                          | 
E                                  | 53         |       10933344 |
 SUI                                          | 
V                                  | 32         |              0 |
 SUI_0                                        | 
SUI                                | 33         |        1429203 |
 SUI_1                                        | 
SUI                                | 34         |        1428665 |
 SUI_2                                        | 
SUI                                | 35         |        1428526 |
 SUI_3                                        | 
SUI                                | 36         |        1428373 |
 SUI_4                                        | 
SUI                                | 37         |        1428597 |
 SY                                           | 
E                                  | 54         |        3248686 |
 twrex                                        | 
E                                  | 14         |         466611 |
 V                                            
|                                    | 9          |              0 |
----------------------------------------------+------------------------------------+------------+----------------+
 TOTAL = 
59                                                                              
              
199052877 |
----------------------------------------------+------------------------------------+------------+----------------+


On Monday, September 28, 2015 at 11:28:57 AM UTC-4, bharath dandala wrote:
>
> Hi All,
> I  have three different classes and  CUI--->SENTENCE <--RELATION
>
> CUI and SENTENCE are connected by hasCui edge.
>
> SENTENCE and RELATION are connect by twrex edge.
>
> I want to find vertices of class B 1) given 2 entries of class CUI   2) 
> One entry from class CUI and one entry from Class RELATION.
>
> I have indexes on ref_id of class A ref_id of class B and ref_id of class 
> C. I also have indexes on hasCui edge.
>
> Here are my queries:
>
>
>   orientdb {db=emerald}> *explain select ref_id from (select 
> expand(in('hasCui')) from CUI where ref_id='C0024530') where 
> out('hasCui').ref_id contains 'C0013090'*
>
> rofiled command 
> '{expandElapsed:1,limit:-1,evaluated:2709,current:#58:2852164,fetchingFromTargetElapsed:5124,documentReads:2709,user:#5:0,recordReads:2709,elapsed:5246.187,resultType:collection,resultSize:35}'
>  
> in 5.247000 sec(s):
>
> {"@type":"d","@version":0,"expandElapsed":1,"limit":-1,"evaluated":2709,"current":"#58:2852164","fetchingFromTargetElapsed":5124,"documentReads":2709,"user":"#5:0","recordReads":2709,"elapsed":5246.187,"resultType":"collection","resultSize":35,"@fieldTypes":"expandElapsed=l,evaluated=l,current=x,fetchingFromTargetElapsed=l,documentReads=l,user=x,recordReads=l,elapsed=f"}
>
>
>
>
>   orientdb {db=emerald}> *explain select ref_id from (select 
> expand(in('hasCui')) from CUI where ref_id='C0024530') where out('hasCui') 
> contains 'C0013090' and out('twrex') contains 'treats'*
>
> Profiled command 
> '{expandElapsed:0,limit:-1,evaluated:2709,current:#58:2852164,fetchingFromTargetElapsed:4880,documentReads:2709,user:#5:0,recordReads:2709,elapsed:4982.7866,resultType:collection,resultSize:0}'
>  
> in 4.983000 sec(s):
>
> {"@type":"d","@version":0,"expandElapsed":0,"limit":-1,"evaluated":2709,"current":"#58:2852164","fetchingFromTargetElapsed":4880,"documentReads":2709,"user":"#5:0","recordReads":2709,"elapsed":4982.7866,"resultType":"collection","resultSize":0,"@fieldTypes":"expandElapsed=l,evaluated=l,current=x,fetchingFromTargetElapsed=l,documentReads=l,user=x,recordReads=l,elapsed=f"}
>
> Each query is taking approximately 5 seconds. It seems my queries are not 
> using indexes. Also, I cannot afford to use lightweight edges as my edges 
> has property. I have indexes on my edge hasCui_idx
>
>
> Here are additional details of my database.
>
> orientdb {db=emerald}> select count(*) from CUI
>
> ----+------+-------
> #   |@CLASS|count  
> ----+------+-------
> 0   |null  |2974236
> ----+------+-------
>
> orientdb {db=emerald}> select count(*) from Sentence
>
> ----+------+-------
> #   |@CLASS|count  
> ----+------+-------
> 0   |null  |2853697
> ----+------+-------
>
>
> orientdb {db=emerald}> select count(*) from RELATION
>
> ----+------+-----
> #   |@CLASS|count
> ----+------+-----
> 0   |null  |12   
> ----+------+-----
>
> orientdb {db=emerald}> select count(*) from twrex   
>
> ----+------+------
> #   |@CLASS|count 
> ----+------+------
> 0   |null  |466611
> ----+------+------
>
> orientdb {db=emerald}> select count(*) from hasCui
>
> ----+------+--------
> #   |@CLASS|count   
> ----+------+--------
> 0   |null  |49970218
> ----+------+--------
>
> orientdb {db=emerald}> list 
> indexes                                                                       
>                     
>
>
>
> INDEXES
>
> ----------------------------------------------+------------+-----------------------+----------------+------------+
>  NAME                                         | TYPE       |         
> CLASS         |     FIELDS     | RECORDS    |
>
> ----------------------------------------------+------------+-----------------------+----------------+------------+
>  AUI.ref_id                                   | UNIQUE_... | 
> AUI                   | ref_id         |    8736353 |
>  AUI_0.ref_id                                 | UNIQUE_... | 
> AUI_0                 | ref_id         |    1747126 |
>  AUI_1.ref_id                                 | UNIQUE_... | 
> AUI_1                 | ref_id         |    1747277 |
>  AUI_2.ref_id                                 | UNIQUE_... | 
> AUI_2                 | ref_id         |    1747741 |
>  AUI_3.ref_id                                 | UNIQUE_... | 
> AUI_3                 | ref_id         |    1746487 |
>  AUI_4.ref_id                                 | UNIQUE_... | 
> AUI_4                 | ref_id         |    1747722 |
> * CUI.ref_id                                   | UNIQUE_... | 
> CUI                   | ref_id         |    2974236 |*
>  CUI_0.ref_id                                 | UNIQUE_... | 
> CUI_0                 | ref_id         |     594601 |
>  CUI_1.ref_id                                 | UNIQUE_... | 
> CUI_1                 | ref_id         |     594779 |
>  CUI_2.ref_id                                 | UNIQUE_... | 
> CUI_2                 | ref_id         |     594842 |
>  CUI_3.ref_id                                 | UNIQUE_... | 
> CUI_3                 | ref_id         |     594248 |
>  CUI_4.ref_id                                 | UNIQUE_... | 
> CUI_4                 | ref_id         |     594394 |
>  dictionary                                   | DICTIONARY 
> |                       |                |          0 |
>  ENTITY.ref_id                                | UNIQUE_... | 
> ENTITY                | ref_id         |         22 |
> * hasCui_IDX                                   | NOTUNIQUE  | 
> hasCui                | in             |   44048388 |*
>                                               |            
> |                       | out            |            |
>  LUI.ref_id                                   | UNIQUE_... | 
> LUI                   | ref_id         |    6117226 |
>  LUI_0.ref_id                                 | UNIQUE_... | 
> LUI_0                 | ref_id         |    1223326 |
>  LUI_1.ref_id                                 | UNIQUE_... | 
> LUI_1                 | ref_id         |    1223955 |
>  LUI_2.ref_id                                 | UNIQUE_... | 
> LUI_2                 | ref_id         |    1223304 |
>  LUI_3.ref_id                                 | UNIQUE_... | 
> LUI_3                 | ref_id         |    1223100 |
>  LUI_4.ref_id                                 | UNIQUE_... | 
> LUI_4                 | ref_id         |    1223541 |
>  ORole.name                                   | UNIQUE     | 
> ORole                 | name           |          3 |
>  OUser.name                                   | UNIQUE     | 
> OUser                 | name           |          3 |
> * RELATION.ref_id                              | UNIQUE_... | 
> RELATION              | ref_id         |         12 |*
>  SEMANTIC_TYPE.ref_id                         | UNIQUE_... | 
> SEMANTIC_TYPE         | ref_id         |        138 |
>  SEMANTIC_TYPE.TUI                            | UNIQUE     | 
> SEMANTIC_TYPE         | TUI            |        133 |
>  SUI.ref_id                                   | UNIQUE_... | 
> SUI                   | ref_id         |    7143364 |
>  SUI_0.ref_id                                 | UNIQUE_... | 
> SUI_0                 | ref_id         |    1429203 |
>  SUI_1.ref_id                                 | UNIQUE_... | 
> SUI_1                 | ref_id         |    1428665 |
>  SUI_2.ref_id                                 | UNIQUE_... | 
> SUI_2                 | ref_id         |    1428526 |
>  SUI_3.ref_id                                 | UNIQUE_... | 
> SUI_3                 | ref_id         |    1428373 |
>  SUI_4.ref_id                                 | UNIQUE_... | 
> SUI_4                 | ref_id         |    1428597 |
>
> ----------------------------------------------+------------+-----------------------+----------------+------------+
>  TOTAL = 
> 32                                                                            
>                  
> 93989685 |
>
> -----------------------------------------------------------------------------------------------------------------+
>
>
> Appreciate your help,
> Thanks,
>
> Regards,
> Bharath
>

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