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Caro Aurélio,
Encontrei os seguintes resumos sobre acyclovir X surdez súbita.
Infelizmente acho que não serão de grande ajuda em relação à
unimed...
Id: 99266731 Autor: Stokroos RJ; Albers FW; Schirm J Endereço: Department of Otorhinolaryngology, University Hospital Groningen, The Netherlands Título: Therapy of idiopathic sudden sensorineural hearing loss: antiviral treatment of experimental herpes simplex virus infection of the inner ear Fonte: Ann Otol Rhinol Laryngol; 108(5):423-8, 1999 May. ISSN: 0003-4894 País de publicação: UNITED STATES Idioma: Eng Resumo: Experimental herpes simplex virus type 1 (HSV-1) labyrinthitis provides a model of idiopathic sudden sensorineural hearing loss (ISSHL). Corticosteroids improve the prognosis for hearing recovery in ISSHL, but the effects of acyclovir are unknown. To establish the therapeutic efficacy of acyclovir (Zovirax) and prednisolone in experimental HSV-1 viral labyrinthitis, we induced HSV-1 labyrinthitis in 12 guinea pigs. Three animals received no treatment, 3 received prednisolone, 3 received acyclovir, and 3 received both. Four other animals served as controls, receiving culture medium only. Hearing, HSV-1 antibody titers, and cochlear damage were evaluated. The HSV-1 labyrinthitis caused hearing loss within 24 hours. Combination treatment consisting of prednisolone and acyclovir resulted in earlier hearing recovery and less extensive cochlear destruction compared to prednisolone or acyclovir as a monotherapy. The beneficial effect of this treatment modality remains to be demonstrated in ISSHL (Au) Tipo de publicação: JOURNAL ARTICLE Nome de substância: 0 (Antiviral Agents); 0 (Glucocorticoids, Synthetic); 50-24-8 (Prednisolone); 59277-89-3 (Acyclovir)Id: 96336727 Autor: Hughes GB; Freedman MA; Haberkamp TJ; Guay ME Endereço: Department of Otolaryngology and Communicative Disorders, Cleveland Clinic Foundation, Ohio 44195, USA Título: Sudden sensorineural hearing loss Fonte: Otolaryngol Clin North Am; 29(3):393-405, 1996 Jun. ISSN: 0030-6665 País de publicação: UNITED STATES Idioma: Eng Resumo: Approximately 4000 new cases of sudden hearing loss (SHL) occur annually in the United States, and 15,000 annually worldwide, accounting for approximately 1% of all cases of SHL. Although prevalence studies do not necessarily distinguish between idiopathic and acquired SHL, most cases of spontaneous SHL have no identifiable cause. In this article, the authors assess the cause, history, diagnosis, and treatment of SHL (Au) Tipo de publicação: JOURNAL ARTICLE; REVIEW; REVIEW, TUTORIAL Nome de substância: 396-01-0 (Triamterene); 53-03-2 (Prednisone); 58-93-5 (Hydrochlorothiazide); 59277-89-3 (Acyclovir)93245811 Autor: Chand RP; Jan A; Vyas H Título: Acute sensorineural deafness following herpes simplex infection [letter] Fonte: Eur J Pediatr; 152(4):379, 1993 Apr. ISSN: 0340-6199 País de publicação: GERMANY Idioma: Eng Tipo de publicação: LETTER Nome de substância: 59277-89-3 (Acyclovir)
98393272 Autor: Stokroos RJ; Albers FW; Tenvergert EM Endereço: Department of Otorhinolaryngology, University Hospital, Groningen, The
Netherlands Título: Antiviral treatment of idiopathic sudden sensorineural hearing loss: a
prospective, randomized, double-blind clinical trial Fonte: Acta Otolaryngol; 118(4):488-95, 1998 Jul. ISSN: 0001-6489 País de publicação: NORWAY Idioma: Eng Resumo: A subclinical viral labyrinthitis has been postulated in the literature
to elicit Idiopathic Sudden Sensorineural Hearing Loss. An etiological
role for the herpes virus family is assumed. Corticosteroids possess a
limited beneficial effect on hearing recovery in ISSHL. In this study, the
therapeutic value of the antiherpetic drug aciclovir (Zovirax) on hearing
recovery in 44 ISSHL patients receiving prednisolone is evaluated in a
multicentre clinical trial. The study is designed prospectively,
randomized, double-blind and placebo-controlled. Subjective parameters
include hearing recovery, a pressure sensation on the affected ear,
disequilibrium or vertigo and tinnitus. Audiometric parameters include
pure tone and speech audiometry. A one-year follow up is obtained. Both
the pressure sensation and disequilibrium or vertigo have a good
prognosis, but tinnitus, occurring in most patients, has a poor prognosis.
Hearing recovery prognosis depends on the severity of initial hearing
loss, and not on vestibular involvement. No beneficial effect from
combining aciclovir with prednisolone can be established in ISSHL
(Au) Tipo de publicação: CLINICAL TRIAL; JOURNAL ARTICLE; MULTICENTER STUDY; RANDOMIZED
CONTROLLED TRIAL Nome de substância: 0 (Anti-Inflammatory Agents, Steroidal); 0 (Antiviral Agents); 50-24-8
(Prednisolone); 59277-89-3 (Acyclovir)
Saudações,
Jorge Pierre, Crato-CE
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[otorri.] =?iso-8859-1?Q?Re:_=5Botorri.=5D_SURDEZ_S=DABITA_-_PROTOCOLO_de_TRATAMENTO?=
Jorge Henrique Arrais de Alencar Pierre Wed, 25 Oct 2000 20:30:33 -0700
- [otorri.] SURDEZ S?BITA - PROTOCOL... Aurélio Pereira de Medeiros
- [otorri.] Re: [otorri.] SURDE... Claudio Ikino
- Jorge Henrique Arrais de Alencar Pierre
