See EX170187 in the service health center.

Title: Unable to receive/send email from/to on-premises environment User 
impact: Users may be experiencing delays or may be unable to send and receive 
email. More info: Admins may encounter one or more of the following symptoms: - 
Admins may see "Connection refused" error in Message Trace or SMTP protocol 
logs. - Admins may receive a notification stating "Messages from Office 365 
using connector 'Outbound On-Premises Connector' have been deferred for more 
than 1 hour." We've communicated in the Message Center that we were making 
updates to Exchange Online Protection (EOP) to help your organization configure 
and update network perimeter devices as well as simplify IP range management. 
As we have received some reports from users that they're experiencing issues 
related to these updates, and may have missed the Message Center posts, we're 
providing additional information. If your organization is experiencing behavior 
similar to what is described, please review the following information. Current 
status: To ensure proper mail flow, organizations that are configured for 
hybrid mail flow or subscribe to Exchange Online Protection (EOP) must make 
sure that their on-premises network allows connections from all of the current 
EOP IP address ranges. Please update your on-premises network allow list to 
accept connections from all of the EOP IP address ranges listed in the 
following link: 
https://docs.microsoft.com/en-us/office365/SecurityCompliance/eop/exchange-online-protection-ip-addresses.
 Scope of impact: This impacts organizations that are configured for hybrid 
mail flow or subscribe to EOP who have not listed the noted IP addresses.

Jason Posner
Senior Systems Administrator
Weis Markets, Inc
Office: 570-863-2874
Cell: 570-975-9938

From: Outages [mailto:[email protected]] On Behalf Of Robbins, David 
via Outages
Sent: Monday, December 10, 2018 10:14 AM
To: [email protected]
Subject: [outages] Intermittent Connectivity Issues - Office 365

We've verified intermittent connectivity issues between local Outlook 
clients/mobile devices and Office 365.

Thanks,

Dave Robbins

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