Have you fired up fiddler and see what the payload of the ajax post is?
It could be something obscure like a too long url post (or a get not a post)
Is the site posting/querying to another domain?  could it be some sort of
xss thing.  (I know you said its posting to the same site, is it perhaps
retrieving assets from another site/domain?)

Have you tried another browser, the thinking is mayby if you are on IE, IE
received a security patch that tightened some flaw or something which you
may of relied on and can't no longer.   Tying firefox/opera see if the
result is the same.



On Thu, May 13, 2010 at 3:54 PM, Dylan Tusler <
[email protected]> wrote:

>  We've suddenly (this week) started getting "Permission denied" errors on
> some of our internal websites (page loads fine, but a little "Error on
> page." appears in the bottom left corner, and behind it is a "Permission
> Denied" error. Some functionality doesn't work, specifically it appears to
> be choking on a JavaScript POST to another page on the same site.)
>
>

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