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Thanks, that looks like it, and if not will
certainly fit the bill! Thanks, Laraine
----- Original Message -----
Sent: Sunday, June 29, 2003 10:30
PM
Subject: Re: [ozmidwifery] [Ozmidwifery]
Asthma & Antibiotics
| . |
20030131-2 The importance of prenatal
exposures on the development of allergic disease: a birth cohort study
using the West Midlands General Practice
Database - American Journal of Respiratory Care Medicine , vol
166, no 6, September 2002, pp 827-832 McKeever TM; Lewis SA; Smith
C; et al - (2002) |
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The etiology of allergic disease is not understood,
but a decreased exposure to infection may play an important role. There
are few published data on the impact of change in microbial exposure
during pregnancy on the child's risk of developing allergic disease.
Using a birth cohort of 24,690 children, derived from the West Midlands
General Practice Research Database, we investigated a number of
perinatal exposures on the incidence of asthma, eczema, and hay fever.
Our findings suggest that exposure to antibiotics in utero is associated
with an increased risk of asthma in a dose-related manner (more than two
courses of antibiotics compared with none adjusted hazard ratio [HR]
1.68; 95% confidence interval [CI], 1.51-1.87), and similar associations
are present for eczema (adjusted HR 1.17; 95% CI, 1.06-1.29) and hay
fever (adjusted HR 1.56; 95% CI, 1.22-2.01). Exposure to a range of
infections in utero was also associated with a small increased risk of
developing allergic disease. Strong protective effects of older siblings
on the incidence of allergy are present within this cohort, but previous
pregnancies that did not result in a live birth were not protective. Our
findings suggest that exposure to antibiotics and to infections in utero
is a potentially important risk factor in the development of allergic
disease. (Author) |
Hi
Larraine,
Is this the one? I found it on
the MIDIRS site.
Cheers,
Sadie
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