They have started using misoprostol here in Australia; W&CH SA were doing studies in it using women but assured me they would not be using VBAC women as VBAC is a contra-indication for using the drug.  These were the same people who were/are doing the ACTOBAC trial. 
The thing that worries me is they say it is not suitable and for darn good reason, but then it becomes the norm for nonvbacs and then over time it starts to be used and whammo!  VBAC is once again endangered not by being a vbac but by mismanagement.  A great number of the studies into the safety of vbac are ones done where induction drugs such as this is used....and they wonder why Uterine Rupture occurs!!!
sorry...just venting!!!
Jo
----- Original Message -----
From: Jen Semple
Sent: Sunday, April 18, 2004 11:21 AM
Subject: Re: [ozmidwifery] VBAC

How common is the use of misoprostol for induction in Australia?
 
I've read it's used quite a lot in the US & that it's used in abortion in Australia, but all I've seen used for induction (in my 2 years as a mid student) in Oz is Prostin.
 
Would love to hear your thoughts/experiences.
 
Jen
3rd year BMid, Melbourne

Mary Murphy <[EMAIL PROTECTED]> wrote:
20040414-39 Uterine rupture  associated with misoprostol labor induction in women with previous cesarean delivery - European Journal of Obstetrics and Gynecology and Reproductive Biology , vol 113, no 1, March 2004, pp 45-48 Aslan H; Unlu E; Agar M; et al - (2004)
  OBJECTIVE: To review our experience with uterine rupture in patients undergoing a trial of labor with a history of previous cesarean delivery in which labor was induced with misoprostol. STUDY DESIGN: A retrospective chart review was used to select patients who underwent induction of labor with misoprostol during the period from February 1999 to June 2002. Women with a history of cesarean delivery were retrospectively compared with those without uterine scarring. RESULTS: Uterine rupture occurred in 4 of 41 patients with previous cesarean delivery who had labor induced with misoprostol. The rate of uterine rupture (9.7%) was significantly higher in patients with a previous cesarean delivery (P<0.001). No uterine rupture occurred in 50 patients without uterine scarring. Women with a history of cesarean delivery were more likely to have oxytocin augmentation than those without uterine scar! ring (41% versus 20%; P=0.037). CONCLUSION: Misoprostol induction of labor increases the risk of uterine rupture in women with a history of cesarean delivery. (16 references) (Author)
Article Type:  Original research
Standard Search: P107 L14 L21 
Yet VBAC  women are still being induced this way.  4 out of 41 is pretty definite.  M



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