If anyone is interested I found the issue was with the DOCICON.XML file in the 
12 hive... a previous developer had added a tag and not closed it, which seemed 
to completly break all the file associations. Not a very helpful error 
message.. and took me half a day to track it down.
 
Blog here about it if anyone wants -
http://my-sharepointer.blogspot.com/2009/08/unable-to-open-office-documents-from.html
 
Cheers

Damian Worrad
[email protected]


      
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