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Summary: Review Request: MACS - Model-based Analysis for ChIP-Seq https://bugzilla.redhat.com/show_bug.cgi?id=716400 Summary: Review Request: MACS - Model-based Analysis for ChIP-Seq Product: Fedora Version: rawhide Platform: All OS/Version: Linux Status: NEW Severity: medium Priority: medium Component: Package Review AssignedTo: [email protected] ReportedBy: [email protected] QAContact: [email protected] CC: [email protected], [email protected] Estimated Hours: 0.0 Classification: Fedora Story Points: --- Spec URL: http://verdurin.fedorapeople.org/reviews/MACS/MACS.spec SRPM URL: http://verdurin.fedorapeople.org/reviews/MACS/MACS-1.4.0-1.fc16.src.rpm Description: Next generation parallel sequencing technologies made chromatin immunoprecipitation followed by sequencing (ChIP-Seq) a popular strategy to study genome-wide protein-DNA interactions, while creating challenges for analysis algorithms. We present Model-based Analysis of ChIP-Seq (MACS) on short reads sequencers such as Genome Analyzer (Illumina / Solexa). MACS empirically models the length of the sequenced ChIP fragments, which tends to be shorter than sonication or library construction size estimates, and uses it to improve the spatial resolution of predicted binding sites. MACS also uses a dynamic Poisson distribution to effectively capture local biases in the genome sequence, allowing for more sensitive and robust prediction. MACS compares favorably to existing ChIP-Seq peak-finding algorithms, is publicly available open source, and can be used for ChIP-Seq with or without control samples. -- Configure bugmail: https://bugzilla.redhat.com/userprefs.cgi?tab=email ------- You are receiving this mail because: ------- You are on the CC list for the bug. _______________________________________________ package-review mailing list [email protected] https://admin.fedoraproject.org/mailman/listinfo/package-review
