In the case of Audacity, the only two differences between using the
installer and the portable version are:
1. If you use the installer, the installed version is automatically
available to all users on the computer.
2. The portable version does not include a copy of the manual. However, you
can download this separately if you wish.
I have a related question. I note that there is a full install version and
a portable version of Audacity. I have noted that many programs have
both a full
install and a portable version. So I conclude that there must be some advantage
of the full install over the portable version of a program. If this is
correct, just what is the advantage specifically in the case of Audacity?