Dear Sung,

This is a great news if it is true. I really hope this will turn out true after "due diligence". There will need to be work done on my side to become apt in some of the principles that you mentioned.

Best,

Danko

On 27/03/15 17:34, Sungchul Ji wrote:
Peircers,

If what I say in the forwarded email turns out to be valid in principle, molecular biology, cell biology, brain sciences, and semiotics may be finally converging on a common set of principles, some, if not all, of which may have more than one names, e.g., practopoiesis, semiosis, teleodynamics, goal-directed processes, gnergetic processes, etc.

All the best.

Sung




---------- Forwarded message ----------
From: *Sungchul Ji* <[email protected] <mailto:[email protected]>>
Date: Fri, Mar 27, 2015 at 12:15 PM
Subject: 'Practopoietons', Peircean signs, and gnergons
To: [email protected] <mailto:[email protected]>
Cc: biosemiotics <[email protected] <mailto:[email protected]>>


Dear Danko,

I largely agree with what Edwina said about the possible connection between your practopoiesis and Peircean semiotics.

Based on what little I know about your work, it seems to me that your "practopoiesis" may be related to Peirce's "semiosis", or "sign process".

Furthermore, if we name the basic unit or mechanism that implements your practopoiesis as the "practopoieton" (please excuse my nelogosism here), the "practopoieton" may be synonymous with the Peircean sign which I have postulated to be synonymous with the gnergon, the hypothetical unit of communication and organization embodying information (gn-) (e.g., nucleotide sequences of DNA) and energy (-ergon) (e.g., DNA supercoils) [1]. Two examples of gnergons are known in biology so far --

(i) conformons, i.e., the conformational strains and waves (e.g., cyclical conformational changes in F1 ATPase of myosin observed with atomic force microscopy) that drive all goal-directed motions of biopolymers [2], and

(ii) IDS's, intracellular dissipative structures (e.g., action potentials, calcium waves in the cytosol) thought to act as the immediate causes for all cellular actions [3]. Recent evidence suggests that IDS's may be identified with the standing waves of metabolite concentrations (e.g., mRNA waves) inside the cell [4].

If you have any questions, comments, or suggestions, let me know.

All the best.

Sung


References:
[1] Ji, S. (2012). Peircean Signs as Gnergons. In: Molecular theory of the Living Cell: Concepts, Molecular Mechanisms, and Biomedical Applications.Springer, New York. Pp. 176-180. PDF athttp://www.conformon <http://www.conformon/>,net under Publications> Book Chapters.
      [2] Ji, S. (2012).  ibid.  Pp. 230-253.
      [3] Ji, S. (2012).  ibid.  Pp. 255-259.
[4] Ji, S. (2015). Planckian distributions in molecular machines, living cells and brains: The wave-particle duality in biomedical applications. Proceedings of the International Conference on Biology and Biomedical Engineering. Vienna, March 15-17, 2015. Pp. 115-137. Attached.


--
Sungchul Ji, Ph.D.

Associate Professor of Pharmacology and Toxicology
Department of Pharmacology and Toxicology
Ernest Mario School of Pharmacy
Rutgers University
Piscataway, N.J. 08855
732-445-4701 <tel:732-445-4701>

www.conformon.net <http://www.conformon.net>



--
Sungchul Ji, Ph.D.

Associate Professor of Pharmacology and Toxicology
Department of Pharmacology and Toxicology
Ernest Mario School of Pharmacy
Rutgers University
Piscataway, N.J. 08855
732-445-4701

www.conformon.net <http://www.conformon.net>


--
Prof. Dr. Danko Nikolić

Web:
http://www.danko-nikolic.com

Mail address 1:
Department of Neurophysiology
Max Planck Institut for Brain Research
Deutschordenstr. 46
60528 Frankfurt am Main
GERMANY

Mail address 2:
Frankfurt Institute for Advanced Studies
Wolfgang Goethe University
Ruth-Moufang-Str. 1
60433 Frankfurt am Main
GERMANY

----------------------------
Office: (..49-69) 96769-736
Lab: (..49-69) 96769-209
Fax: (..49-69) 96769-327
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