Members, The Peirce list has been relatively quiet over the past few days. Perhaps this is an opportune moment to introduce a different kind of exploratory perspective.
My thinking sprawls across several disciplines and experiences, and so people often have trouble following where Im coming from. Lets see if we can distill everything into a few short lines, in one place, to explore why the DNA molecule might perhaps provide the key to life, the universe and everything. 1) The semiotics of CS Peirce plays a fundamental part in my reasoning. But I also extend Peircean semiotics to the biosemiotics of Jakob von Uexküll, down to habituation and associative learning in single cells (e.g., with reference to the work of Eric Kandel on habituation and association in Aplysia, or AH Klopf on association); 2) Entropy needs to be taken seriously. No, not the over-intellectualized entropy of the 2nd law of thermodynamics, but the tendency to disorder as per Shannon entropy. Here is an excellent review of the entropy issues as they relate to evolution by natural selection (Beisner 1987, with reference to the work of Byles 1972): https://www.icr.org/article/270; 3) One can get an intuitive appreciation of the scale of the entropy problem from this video, Inner Life of the Cell, which is a simulation of the incredibly complex goings-on inside the cell. Incredible complexity is one thing. But that it persists across time is quite another, and the onus is on the Darwinists (especially Neo-Darwinists) to prove that their natural selection theory has properly dealt with entropy. Their onus of proof remains outstanding. Video from More Thinking: https://youtu.be/FzcTgrxMzZk; 4) Intelligent Design (ID) has competently addressed the most salient issues before, such as irreducible complexity and entropy. But then they go and spoil it all with their human exceptionalism. Human exceptionalism has no place in science. Converging on the god question certainly might, but indulging in value-judgments about how exceptional humans are, does not. That the folk of ID do this demonstrates their failure to understand key ontological/phenomenological issues, which are more potently addressed within the semiotic/biosemiotic paradigm. The same biological principles must apply to all organisms, including human, otherwise it is not biology that they are studying. If they want to celebrate their humanity, then by all means go for it, but please don't call it science; 5) Quantum mechanics and nonlocality. Is the self nonlocal? I have reason to suggest that it is. The local self, by contrast, is an assumption, an illusion based on the fact that all experience can only ever take place in a localized context; 6) At least in the context of epigenetic theory, it is widely accepted that experience changes DNA (which genes are expressed); 7) At least in the context of Darwinian natural selection, it is now widely accepted that experience wires the neuroplastic brain; 8) The previous two points (6 and 7), however, suffer from the shortcomings of the Darwinian paradigm, which is inconsistent with entropy. The notion of "adaptive traits" is particularly problematic in this regard. Neural plasticity is not merely an incidental "adaptive trait", but absolutely fundamental to the way that single cells, such as neurons, make choices from their ecosystems. This is more effectively interpreted through the Peircean-biosemiotic paradigm (I believe the term "scaffolding" applies. Systems theorists use the word "autopoiesis"); 9) Neural plasticity and cellular autopoiesis (self-organization) relate to systems theory. If experiences wire the brain, it then follows that experiences are contingent on the body with which they are apprehended. In the context of human culture, human experiences are apprehended by male and female bodies. Our outline sets the stage for properly understanding sex differences and gender roles in culture. Particularly within the context of evolution, the cultural known and the unknown. Here is a web article that nudges onto the significance of this point, particularly in the context of the primary nurturer (Ibelle, 2018, citing Lisa Feldman Barrett and Atzil et al, 2018): https://news.northeastern.edu/2018/08/06/what-if-people-from-different-cultu res-and-economic-backgrounds-have-different-brain-wiring/ 10) Do we follow where this is taking us? Mind precedes matter. Only by taking this route, might we be better able to address the entropy problem. Entanglement and imitation tend to structure and order. Richard Dawkins was on the right track with his memetic theory... how unfortunate that he allowed this to languish, in favor of his selfish gene narrative. Both selfish genes and selfish people increase entropy because they act contrary to the interests of structure and order; 11) Eastern religions, most notably Buddhism, converge on these sorts of questions quite impressively. Though I suggest that Peirce has something to contribute to the Buddhist narrative, with respect to pragmatism. According to Buddhism, desire (Tanha) is the source of all problems. But desire relates to motivation (firstness), which relates to pragmatism and "knowing how to be". Let us designate "imitation" as shorthand for this "knowing how to be". Tanha is secondary to imitation. It is imitation (pragmatism), in the sense of knowing how to be, that first establishes the things that matter... the things that one should desire and fear. Incorrect imitation is the source of all problems, not desire. Tanha is downstream from imitation. It is through imitation (in the more nuanced sense of knowing how to be) that we learn what to desire; 12) Structure and order, imitation and entropy... has relevance to everything political, from blindly imitated groupthink and tyranny, to courageously fought-for freedom and democracy; 13) We now know that the same dumb dirt that makes The Inner Life of the Cell possible is the same dumb dirt that exists elsewhere throughout the cosmos. The Inner Life of the Cell would not be possible were dumb dirt not so smart; 14) We now know that the number of galaxies in the universe is of the order of trillions (2 trillion guesstimated at last count, though I suggest that the number might be closer to infinite). With billions of stars per galaxy, that's a lot of possibilities for a nonlocal self to be reincarnated into, and there will be no shortage of possible configurations to accommodate; 15) On the assumption that the self is nonlocal, it follows that each and every one of us will enter our next culture with the same innocence that we entered into this one. We will be wholly dependent on our primary nurturer to introduce us to the basic assumptions governing our new home. We won't remember our current existence nor our current sex. Both the law of entropy and the no-communication theorem prohibit the transfer of information. Adolf Hitler and Josef Stalin have been reborn as helpless innocents, whether male or female. An innocent child is an innocent child, but in their new homes, they have new cultural unknowns to contend with. And that's a scary thought. Good luck Adolf and Josef, you'll both need it... but at least your mothers might love you; 16) My article, Quantum Semiotics, explores some of the most salient issues as they apply in this outline: http://journals.sfu.ca/jnonlocality/index.php/jnonlocality/article/view/64/6 3 17) The initial motivation for my paper, Quantum Semiotics, was the topic of DNA entanglement. And on the basis of evidence to date, we can confirm that entanglement applies not just to the smallest subatomic particles, but also to the largest of molecules. And therefore to DNA. The following reference on DNA replication, with video, is particularly interesting, because it challenges mainstream (deterministic) interpretations on how replication proceeds (Crew, B. 2018, citing the work of Graham et al 2017): https://www.sciencealert.com/dna-replication-first-footage-unexpected Sure, I have made some unfalsifiable conjectures here. But this is my condensed, all-inclusive picture, how I see things. And at least I frame this unfalsifiable conjecture within the context of a solid axiomatic framework. Is DNA the key to understanding the relationship between culture, personality, reincarnation, karma and heaven and hell? No matter how we look at it, there's something strange going on, and nobody gets it. How little we know. So much to wrap our heads around. So much paradigm to shift. This is my feeble stab at it. Stephen Jarosek BIBLIOGRAPHY Atzil S., Gao W., Fradkin I. and Feldman Barrett L. (2018). Growing a Social Brain. Nature Human Behaviour volume 2, pages 624636. Beisner, E. Calvin (1987). Mutation Fixation: A Dead End for Macro-evolution. Retrieved October 29, 2018, from https://www.icr.org/article/270 Byles, R. H. (1972, March). Limiting Conditions for the Operation of the Probable Mutation Effect. Social Biology, 19:1 29-34. Retrieved April 10, 2016, from http://www.tandfonline.com/doi/abs/10.1080/19485565.1972.9987962?journalCode =hsbi19 Crew, B. (2018). This is the first detailed footage of DNA replication, and it wasn't what we expected. Sciencealert.com. Retrieved 29 October, 2018, from https://www.sciencealert.com/dna-replication-first-footage-unexpected Graham J.E., Marians K.J., Kowalczykowski S.C. (2017). Independent and Stochastic Action of DNA Polymerases in the Replisome. Cell, 169/7, pp 1201-1213. Ibelle, B. (2018). What If People From Different Cultures And Economic Backgrounds Have Different Brain Wiring. News@Northeastern. Retrieved October 29, 2018 from https://news.northeastern.edu/2018/08/06/what-if-people-from-different-cultu res-and-economic-backgrounds-have-different-brain-wiring/ Jarosek, S. (2017). Quantum Semiotics. J. Nonlocality: Special Issue on Psi and Nonlocal Mind, 2017 http://journals.sfu.ca/jnonlocality/index.php/jnonlocality/article/view/64/6 3 Kandel, E. R. & Hawkins, R. D. (1992). The biological basis of learning and individuality. Scientific American: Mind and Brain, 267(3), 53-60. Klopf, A. H. (1982). The hedonistic neuron: A theory of memory, learning and intelligence. Washington, DC: Hemisphere. MoreThinking. Inner Life of the Cell (Full Version - Narrated). [YouTube - XVIVO for Harvard University]. January 9, 2013. Retrieved April 04, 2016, from https://www.youtube.com/watch?v=FzcTgrxMzZk DISCLAIMER No cells, plants or animals were harmed in the creation of this post. No woo was entertained to deliver on the facts.
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