I would second Jim's suggestion ("the problem is that it's incomplete") in the case of 
a short presentation. THe focus on preference formation and the role of institutions 
in this is also a good idea.

Just pointing out the implications of "endogenous preferences" tends to undercut all 
the "welfare" conclusions of NC theory. Herb Gintis' 1970s work (in AER 1974 May, I 
think, and other places) points out some of the implications of endogenous 
preferences, adaptive preferences, and feedback effects. See also 
http://www.zmag.org/books/4/4.htm and references therein.

While for a "static analysis" one _might_ assume exogenous preferences, for any story 
about grwoth and change over time endogenous preferences are important and such 
preferences can't be taken about of by mainstream economics.

Alternatively, you could focus on technology development and technology choice: a 
large literature exists on this which directly undercuts NC theories of exogenous 
technology development and so on.

More fundamental is the (lack of) treatment in NC theory of power in its various 
manifestations. BUt this would be a much more challenging issue to tackle in a short 
presentation.
 

Eric
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What a big order! If I were to be forced to talk about this subject, I'd stick to the 
basic point that "the problem with mainstream economics is not that it's wrong in its 
own terms as much as that it's incomplete." For example, the mainstream's "new 
institutional economics" (NIO) is a matter of explaining the form of institutions in 
terms of technology (including transactions costs) and individual tastes, which are 
given at any one time. But this leaves out the way in which the institutional form 
_feeds back_ to help determine the types of technology developed and applied and the 
preferences and expectations of individuals. It thus ignores the way in which 
institutions can "take on a life of their own," developing independently of 
exogenously-given technologies and preferences. 
 
There was a good contrast in the JOURNAL OF ECONOMIC LITERATURE, where Oliver 
Williamson presented the NIO (September 2000, vol. 38, number 3) and Geoffrey Hodgson 
(March 1998, vol. 36, number 1). It's interesting that even though the former wrote 
after the latter, he ignored the latter's contribution. (Perhaps arrogance is a 
characteristic of the mainstream?)

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