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Acromegaly with Apparently Normal GH Secretion
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From:
![]() ![]() Acro1974
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http://jcem.endojournals.org/cgi/content/full/87/8/3537 Acromegaly with Apparently Normal GH Secretion: Implications for Diagnosis and Follow-Up The biochemical diagnosis of acromegaly is conventionally based on elevated plasma GH levels that fail to suppress after an oral glucose load. We studied 16 newly diagnosed patients with acromegaly with normal mean plasma GH but elevated age and gender-adjusted plasma IGF-I concentrations (476 ± 29 µg/liter, mean ± SE). Plasma GH was sampled every 10 min for 24 h, and an oral glucose tolerance test was performed. The control group included 46 healthy subjects. All patients had 24-h mean GH values that overlapped with those of the healthy controls. Mean plasma GH was less than 2.5 µg/liter in 12 patients. Patients had higher 24-h nadir GH values than healthy controls (P < 0.001). During the oral glucose tolerance test, nadir plasma GH was less than 1 µg/liter in eight patients. |
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