We are using Postfix as our MTA with an integration of Amavis, ClamAV,
Spamassassin (3.0.1), and Maia Mailguard. After all the spam and
antivirus check, it sends the email to either the remote server or the
server hosting the mailboxes. We have more or less 45,000 mailboxes in
our mail server.

Our problem in our mail server is when mail queues starts to pile up
due to spam. It causes delay on legit mails that needs to be sent
right away. Postfix reports thousands of mail in its queue and 70% of
them are spam.

Can somebody give suggestions on how we can handle spam mail more
efficiently. Thanks!

Relevant lines in the respective configs are shown below:
Postfix:
main.cf
command_directory = /usr/sbin

daemon_directory = /usr/libexec/postfix

myhostname = (removed for security purposes)

mydomain = (removed for security purposes)

myorigin = $myhostname

inet_interfaces = $myhostname, localhost

unknown_local_recipient_reject_code = 550

mynetworks = (removed for security purposes)

alias_maps = hash:/etc/postfix/aliases

debug_peer_level = 2

debugger_command =
         PATH=/bin:/usr/bin:/usr/local/bin:/usr/X11R6/bin
         xxgdb $daemon_directory/$process_name $process_id & sleep 5

sendmail_path = /usr/sbin/sendmail.postfix

newaliases_path = /usr/bin/newaliases.postfix

mailq_path = /usr/bin/mailq.postfix

setgid_group = postdrop

manpage_directory = /usr/local/man

sample_directory = /etc/postfix/sample

readme_directory = /etc/postfix/sample
alias_database = hash:/etc/postfix/aliases
transport_maps = hash:/etc/postfix/transport

content_filter = smtp-amavis:[127.0.0.1]:10026

smtpd_sender_restrictions =
        check_sender_access hash:/etc/postfix/access
        reject_rhsbl_sender dnsbl.sorbs.net
        reject_rhsbl_sender xbl.spamhaus.org
        reject_rhsbl_sender block.blars.org
        permit_mynetworks
        reject_non_fqdn_sender
        reject_non_fqdn_recipient
        reject_unknown_sender_domain
        reject_unknown_recipient_domain
        reject_sender_login_mismatch
#       reject_unauth_destination
        reject_maps_rbl
        permit
smtpd_recipient_restrictions =
        reject_unlisted_recipient
        check_sender_access hash:/etc/postfix/access
        check_client_access hash:/etc/postfix/access
        permit_mynetworks
        permit_mx_backup
        reject_maps_rbl
        reject_unauth_destination
        reject_rhsbl_sender xbl.spamhaus.org, dnsbl.sorbs.net, block.blars.org
        check_sender_access hash:/etc/postfix/sender_access
        check_policy_service unix:private/policy
maps_rbl_domains = relays.ordb.org, list.dsbl.org, dnsbl.sorbs.net,
whois.rfc-ignorant.org, abuse.rfc-ignorant.org
message_size_limit = 10000000
maximal_queue_lifetime = 2
policy_time_limit = 3600

master.cf
# ==========================================================================
# service type  private unpriv  chroot  wakeup  maxproc command + args
#               (yes)   (yes)   (yes)   (never) (100)
# ==========================================================================
smtp      inet  n       -       y       -       -       smtpd
#submission inet n      -       y       -       -       smtpd
#       -o smtpd_etrn_restrictions=reject
#628      inet  n       -       y       -       -       qmqpd
pickup    fifo  n       -       y       60      1       pickup
cleanup   unix  n       -       y       -       0       cleanup
qmgr      fifo  n       -       y       300     1       qmgr
#qmgr     fifo  n       -       y       300     1       oqmgr
rewrite   unix  -       -       y       -       -       trivial-rewrite
bounce    unix  -       -       y       -       0       bounce
defer     unix  -       -       y       -       0       bounce
trace     unix  -       -       y       -       0       bounce
verify    unix  -       -       y       -       1       verify
flush     unix  n       -       y       1000?   0       flush
proxymap  unix  -       -       n       -       -       proxymap
smtp      unix  -       -       y       -       -       smtp
relay     unix  -       -       y       -       -       smtp
#       -o smtp_helo_timeout=5 -o smtp_connect_timeout=5
showq     unix  n       -       y       -       -       showq
error     unix  -       -       y       -       -       error
local     unix  -       n       n       -       -       local
virtual   unix  -       n       n       -       -       virtual
lmtp      unix  -       -       y       -       -       lmtp
anvil     unix  -       -       y       -       1       anvil
policy    unix  -       n       n       -       -       spawn
 user=nobody argv=/usr/bin/perl /usr/libexec/postfix/greylist.pl -v
#
# Interfaces to non-Postfix software. Be sure to examine the manual
# pages of the non-Postfix software to find out what options it wants.
#
# maildrop. See the Postfix MAILDROP_README file for details.
#
maildrop  unix  -       n       n       -       -       pipe
 flags=DRhu user=vmail argv=/usr/local/bin/maildrop -d ${recipient}
#
#
#
# The Cyrus deliver program has changed incompatibly, multiple times.
#
old-cyrus unix  -       n       n       -       -       pipe
 flags=R user=cyrus argv=/cyrus/bin/deliver -e -m ${extension} ${user}
# Cyrus 2.1.5 (Amos Gouaux)
# Also specify in main.cf: cyrus_destination_recipient_limit=1
cyrus     unix  -       n       n       -       -       pipe
 user=cyrus argv=/cyrus/bin/deliver -e -r ${sender} -m ${extension} ${user}
uucp      unix  -       n       n       -       -       pipe
 flags=Fqhu user=uucp argv=uux -r -n -z -a$sender - $nexthop!rmail ($recipient)
ifmail    unix  -       n       n       -       -       pipe
 flags=F user=ftn argv=/usr/lib/ifmail/ifmail -r $nexthop ($recipient)
bsmtp     unix  -       n       n       -       -       pipe
 flags=Fq. user=foo argv=/usr/local/sbin/bsmtp -f $sender $nexthop $recipient

127.0.0.1:10025 inet    n       -       y       -       -       smtpd
        -o content_filter=
        -o local_recipient_maps=
        -o relay_recipient_maps=
        -o smtpd_restriction_classes=
        -o smtpd_helo_restrictions=
        -o smtpd_sender_restrictions=
        -o smtpd_recipient_restrictions=permit_mynetworks,reject
        -o mynetworks=127.0.0.0/8
        -o strict_rfc821_envelopes=yes
smtp-amavis     unix    -       -       y       -       2       smtp
        -o smtp_data_done_timeout=1200
        -o disable_dns_lookup=yes


Spamassassin:

required_hits   2.5
rewrite_subject 1
rewrite_header  Subject "THIS IS SPAM!"
report_safe     1
# trusted_networks 212.17.35.
use_terse_report        1

subject_tag     *****SPAM*****
use_auto_whitelist 0

auto_learn      1
skip_rbl_checks 0

#use_razor2     0
#razor_timeout  5
#razor_config /var/vscan/.razor/razor-agent.conf

#use_bayes      0
#bayes_auto_learn       1
#bayes_auto_learn_threshold_nonspam     1
#bayes_auto_learn_threshold_spam        14
#bayes_path  /var/vscan/.spamassassin/bayes
#auto_whitelist_path /var/vscan/.spamassassin/auto_whitelist

#use_dcc        0
#dcc_home       /var/dcc
#dcc_dccifd_path /var/run/dcc/dccifd.pid
#dcc_dccifd_path /var/dcc/dccifd
#$dcc_add_header        1

#use_pyzor      1
#pyzor_timeout  5
#pyzor_path     /usr/bin/pyzor
#pyzor_add_header       1


blacklist_from (removed for security purposes)
blacklist_from (removed for security purposes)
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