Hello Peter,
i'm definitely not a MySQL expert but giving a look to the settings you posted 
(and
expecially to that 'key_buffer = 256M') i suspect that all that memory is 
'locked'
because of some overextimated setting. In my little experience with it, a bare 
MySQL
server (for bare i mean as you find it, without touching any my.cnf variable) 
takes
some 30Mb (VSZ), comes with a 'key_buffer = 16M' and attached to a bunch of 
totally
underutilized web sites, creates 20 to 30 processes.

Is pmacct still warning you about the packet loss ? If yes, try either (1) 
pushing up
the value of 'plugin_buffer_size' (mantaining its actual ratio with 
'plugin_pipe_size')
or try (2) increasing the ratio (pushing up 'plugin_pipe_size' but leaving as 
is the
'plugin_buffer_size'). Two examples:

1)  plugin_buffer_size: 8192
   plugin_pipe_size: 8192000

2) plugin_buffer_size: 4096
   plugin_pipe_size: 8192000

Let me know how things get evolved on your side.

Cheers,
Paolo

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