On Thu, Dec 15, 2011 at 11:49:35AM -0800, Gonzo Fernandez wrote:
> /var/log/maillog:Dec 14 04:03:07 batch-ca4-02 postfix/sendmail[12280]: fatal: 
> root(0): queue file write error
> /var/log/maillog:Dec 15 12:03:07 batch-ca4-02 postfix/postdrop[21744]: 
> warning: uid=0: Illegal seek

In addition to what Wietse asked for in another mail just now,
do look at the output of the commands

        mount

        dmesg

That should show if there is a hardware problem.

If it is not, then is it not possible that the 8A2993E3003B you
are worrying about is a locally submitted mail from some system
daemon (like logwatch) that is too big for your configured
system limits? The times on the error messages make me suspect
some kind of cron job.

See:

        http://www.electrictoolbox.com/logwatch-postfix-sendmail-errors/

        
http://www.cyberciti.biz/tips/linux-unix-posttfix-mutt-illegal-seek-error.html

8A2993E3003B would then be a minor consequence of your main
problem, which is mail freezing up over weekends.

To diagnose that problem, it would be interesting to grep on a
queue id that was correctly queued, like (from an earlier mail):

Dec 12 10:08:50 batch-ca4-02 postfix/pickup[26935]: warning: 884643E30022: 
message has been queued for 1 days

Since mails such as those have been correctly queued, there
should be a wealth of information about when and how and why
it's staying in the queue so long.

HTH

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