> On Jul 29, 2016, at 10:16 AM, Shawn Heisey <deb...@elyograg.org> wrote:
> 
> I have no interest in postfix validating "From" headers, but if the
> envelope sender contains one of my domains and the sending server is not
> in mynetworks, I want postfix to reject it.  Is that possible?

Yes, quite possible and widely used.

    main.cf:
        indexed = ${default_database_type}:${config_directory}/
        smtpd_sender_restrictions =
                check_sender_access ${indexed}smtp-from

    smtp-from:
        example.com     permit_mynetworks, reject
        .example.com    permit_mynetworks, reject

-- 
        Viktor.

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