Jesper Dybdal:
> On 2019-09-17 13:02, Wietse Venema wrote:
> > Jesper Dybdal:
> >> Can "Error: queue file write error" mean anything other than a problem
> >> with the queue file?
> > Yes. LOOK IN THE LOGS. Postfix will not reveal internal error details
> > in its responses to random SMTP clients.
> 
> You're right: I had somehow overlooked"timeout talking to proxy 
> 127.0.0.1:10024", which undoubtedly is the problem.? Port 10024 is the 
> pre-queue amavisd-new.
> 
> Now I just need to figure out why amavis times out.

Perhaps amavisd-new is doing slow DNS lookups?

The Postfix-side time limit is covered by smtpd_proxy_timeout which
has a generous default of 100s. Increasing this may result in remote
SMTP client timeouts and duplicate deliveries as the client retries.

        Wietse 

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